Inducible nitric oxide synthase (iNOS) gene deficiency increases the mortality of sepsis in mice
SurgeryPublished 1 August 1999
J. Perren Cobb, Richard S. Hotchkiss, Paul E. Swanson, Kathy Chang, Yuyu Qiu, Victor E. Laubach
Citations111
SJR quartileQ1
SJR score1.09
SNIP1.16
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TL;DR
iNOS gene function provides a survival benefit in septic mice and is associated with increased sepsis-induced thymocyte apoptosis, as determined by histology and two-channel fluorescence-activated cell sorter analysis.
Abstract
We conclude that iNOS gene function provides a survival benefit in septic mice and is associated with increased sepsis-induced thymocyte apoptosis. To our knowledge, this is the first survival study examining the effect of iNOS gene deficiency in a clinically relevant model of sepsis.
Keywords
Immunology and MicrobiologyMedicine
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