Opioid activity of a peptide, beta-lipotropin-(61-91), derived from beta-lipotropin.
Proceedings of the National Academy of SciencesPublished 1 June 1976Open access
Brian M. Cox, A Goldstein, Chernov Hi
Citations264
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TL;DR
The pituitary peptide beta-lipotropin displays essentially no opoid activity in a preparation of guinea pig ileum or in the opiate receptor binding assay, however, a fragment with the enkephalin sequence at its NH2-terminus has typical opioid effects in these two assays.
Abstract
The pituitary peptide beta-lipotropin displays essentially no opoid activity in a preparation of guinea pig ileum or in the opiate receptor binding assay. However, a fragment, beta-lipotropin-(61-91), with the enkephalin sequence (Tyr-Gly-Gly-Phe-Met) at its NH2-terminus, has typical opioid effects in these two assays.
Keywords
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