Toxicology rethinks its central belief
NaturePublished 1 February 2003
Edward J. Calabrese, Linda A. Baldwin
Citations709
SJR quartileQ1
SJR score18.29
SNIP10.16
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TL;DR
Hormesis demands a reappraisal of the way risks are assessed for the first time in 25 years.
Abstract
Hormesis demands a reappraisal of the way risks are assessed.
Keywords
Social Sciences
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These findings challenge the long-standing belief in the primacy of the threshold model in toxicology (and other areas of biology involving dose-response relationships) and provide strong support for the hormetic-like biphasic dose- response model characterized by a low-dose stimulation and a high-dose inhibition.
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