Neurotransmitter markers in the cerebrospinal fluid of normal subjects effects of aging and other confounding factors
Journal of Neural TransmissionPublished 1 February 1991
Päivi Hartikainen, Hilkka Soininen, K. Reinikainen, J. Sirvi�, Raija Soikkeli, Paavo Riekkinen
Citations50
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SJR score1.11
SNIP1.13
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TL;DR
The gender of subjects and seasonal changes, as well as height and weight of the subjects seemed to cause some variations in the levels of HVA, dopamine-Β-hydroxylase (DBH) and ACTH, which underscores the importance of standardized conditions and matched patient groups in the CSF studies.
Abstract
We have investigated neurotransmitter-related markers of the cerebrospinal fluid (CSF) in a carefully screened series of normally aging subjects in standardized conditions in order to find out the influence of age and other confounding factors on CSF measures. The levels of 3-methoxy-4-hydroxyglycol (MHPG) and the activity of acetylcholinesterase (AChE) also increased with age, while homovanillic acid (HVA), 5-hydroxyindoleacetic acid (5 HIAA) and immunoreactivities of somatostatin (SLI), beta-endorphin (BLI) and adrenocorticotropic hormone (ACTH) were unrelated to age. The gender of subjects had no significant effect on the levels of neurotransmitter markers, while seasonal changes, as well as height and weight of the subjects seemed to cause some variations in the levels of HVA, dopamine-beta-hydroxylase (DBH) and ACTH. The study underscores the importance of standardized conditions and matched patient groups in the CSF studies.
Keywords
MedicineNeuroscience
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