Decreased plasma levels of nitric oxide derivatives in obstructive sleep apnoea: response to CPAP therapy
ThoraxPublished 1 December 2000Open access
Richard Schulz
Citations288
SJR quartileQ1
SJR score2.45
SNIP2.08
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TL;DR
Plasma NOx levels are reduced in OSA and can be increased by short and long term CPAP therapy, which may have important implications for the development of cardiovascular disease in patients with Osa and for the life saving effect of CPAP.
Abstract
Plasma NO(x) levels are reduced in OSA and can be increased by short and long term CPAP therapy. Although the precise mechanism underlying this observation remains to be clarified, it may have important implications for the development of cardiovascular disease in patients with OSA and for the life saving effect of CPAP.
Keywords
MedicineNeuroscience
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1,510 Citations1988Jiang He, Meir H. Kryger +3 more
It is concluded that OSA patients with an apnea index of greater than 20 have a greater mortality than those below 20 and that UPPP patients be restudied after therapy and if the latter patients are found not to have marked amelioration of their AI, then they should be treated by nasal CPAP or tracheostomy.
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119 Citations2000H.-W. Duchna, Christian Guilleminault +5 more
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115 Citations1997Yiiksel Peker, Jan Hedner +2 more
NCPAP treatment reduces the need for acute hospital admission due to CVPD in patients with OSAS, and this reduction of concomitant health care consumption should be taken into consideration when assessing the cost-benefit evaluation of nCPAP therapy.
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95 Citations1996Lasse Viinikka
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77 Citations1998Miriam Blum, Tatyana Yachnin +8 more
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64 Citations1995L. P. McQuillan, Gordon Leung +3 more
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35 Citations1999M. Kohno, Koji Yokokawa +6 more
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17 Citations1999An‐Soo Jang, Inseon S. Choi
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6 Citations1998Masayoshi Yagi, Junko Adachi +2 more
The nitric oxide profile produced by application of a pneumatic tourniquet was investigated in the plasma of patients and suggest that the generation of NO is important in ischemic reperfusion injury.