Lipoprotein Movement through Canine Aortic Wail
SciencePublished 15 November 1963
Leroy E. Duncan, Katherin Buck, Almorris Lynch
Citations66
SJR quartileQ1
SJR score10.42
SNIP6.62
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Abstract
Low-density (1.019 to 1.063) lipoprotein labeled with radioiodine enters the inner layer of the canine aortic wall directly from the aortic lumen. Its rate of entry is greatest in the proximal aorta and decreases progressively down the length of the aorta. A similar gradient was observed previously for the accumulation of cholesterol early in experimental atherosclerosis.
Keywords
Medicine
The American Journal of MedicineThe design and analysis of isotope experiments
321 Citations1960D.B. Zilversmit
A number of simple model systems are analyzed and approximate numerical solutions are presented for the investigator who does not require the added precision of more complex mathematical analyses.
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The observed similarities of the entrance rate of labeled albumin in normal dogs, the entrance rates of labeled cholesterol into canine aortic wall, and the rate of accumulation of cholesterol in dogs on an atherogenic regimen do suggest that information about the movement of albumin through arterial wall will provide a pertinent background to the study of the move of lipoproteins through that tissue.
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The similarity of the gradients and the relative magnitude of the rates for cholesterol and albumin support the concept that cholesterol is carried into the aortic wall of the normal dog by the passage of the lipoproteins of which it is a part.
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The aortic concentration of cholesterol, phospholipid, alkali-soluble nitrogen and polysaccharides decreased from arch to trifurcation in normal, allylamine-treated, and steroid-treated castrate dogs; total and alkali -insoluble nitrogen increased.