Diffusion Tensor Imaging in Children with Periventricular Leukomalacia: Variability of Injuries to White Matter Tracts
American Journal of NeuroradiologyPublished 1 August 2007Open access
Lídia Nagae, Alexander H. Hoon, Elaine Stashinko, Doris Lin, W. Zhang, Eric Levey
Citations154
SJR quartileQ1
SJR score1.13
SNIP1.45
Generate an AI Snapshot to get a quick, structured summary of this paper.
Study Snapshot
ObjectiveStudy objective
MethodsResearch methodology
PopulationPopulation studied
Sample sizeSample sizes
OutcomesStudy outcomes here
ResultsStudy results comes here
LimitationsResearch study limitations comes here
A concise AI-generated summary of the paper will appear here once you click Generate AI Snapshot.
TL;DR
The tract-specific evaluation of diffusion tensor imaging revealed a family of tracts that are highly susceptible in PVL, important information that can potentially be used to tailor treatment options in the future.
Abstract
DTI is a suitable technique for in vivo assessment of specific white matter lesions in patients with PVL and, thus, a potentially valuable diagnostic tool. The tract-specific evaluation revealed a family of tracts that are highly susceptible in PVL, important information that can potentially be used to tailor treatment options in the future.
Keywords
Medicine
Annals of NeurologyThree-dimensional tracking of axonal projections in the brain by magnetic resonance imaging
3,527 Citations1999Susumu Mori, Barbara J. Crain +2 more
It is shown that neuronal pathways in the rat brain can be probed in situ using high‐resolution three‐dimensional diffusion magnetic resonance imaging and a newly designed tracking approach.
Magnetic Resonance in MedicineToward a quantitative assessment of diffusion anisotropy
2,428 Citations1996Carlo Pierpaoli, Peter J. Basser
New indices calculated from the entire diffusion tensor are rotationally invariant (RI) and show that anisotropy is highly variable in different white matter regions depending on the degree of coherence of fiber tract directions.
NMR in BiomedicineFiber tracking: principles and strategies – a technical review
2,029 Citations2002Susumu Mori, Peter C.M. van Zijl
The state of the art of reconstruction of the axonal tracts in the central nervous system (CNS) using diffusion tensor imaging (DTI) is reviewed, including both data acquisition and the elaborate fiber reconstruction algorithms.
RadiologyFiber Tract–based Atlas of Human White Matter Anatomy
2,005 Citations2004Setsu Wakana, Hangyi Jiang +3 more
Two- and three-dimensional white matter atlases were created on the basis of high-spatial-resolution diffusion tensor magnetic resonance (MR) imaging and 3D tract reconstruction and showed which anatomic structures can be identified on diffusion Tensor images and where these anatomic units are located at each section level and orientation.
Journal of Computer Assisted TomographyRapid Automated Algorithm for Aligning and Reslicing PET Images
1,934 Citations1992Roger P. Woods, Simon R. Cherry +1 more
Proceedings of the National Academy of SciencesTracking neuronal fiber pathways in the living human brain
1,786 Citations1999Thomas E. Conturo, Nicolás Lori +7 more
This approach enhances the power of modern imaging by enabling study of fiber connections among anatomically and functionally defined brain regions in individual human subjects.
NeuroImageVirtual in Vivo Interactive Dissection of White Matter Fasciculi in the Human Brain
1,651 Citations2002Marco Catani, Robert Howard +2 more
The use of diffusion tensor magnetic resonance tractography to visualize the three-dimensional structure of the major white matter fasciculi within living human brain adds a new dimension to anatomical descriptions of the living humanbrain.
Magnetic Resonance in MedicineOptimal strategies for measuring diffusion in anisotropic systems by magnetic resonance imaging
1,420 Citations1999Derek K. Jones, Mark A. Horsfield +1 more
An algorithm is presented that minimizes the bias inherent in making measurements with a fixed set of gradient vector directions by spreading out measurements in 3‐dimensional gradient vector space and this results in reduced scan times, increased precision, or improved resolution in diffusion tensor images.
Magnetic Resonance in MedicineColor schemes to represent the orientation of anisotropic tissues from diffusion tensor data: application to white matter fiber tract mapping in the human brain
778 Citations2000Sinisa Pajevic, Carlo Pierpaoli
Directionally encoded color (DEC) maps of the human brain obtained using empirical or heuristic schemes clearly show the main association, projection, and commissural white matter pathways.
RadiologyNormal brain in human newborns: apparent diffusion coefficient and diffusion anisotropy measured by using diffusion tensor MR imaging.
644 Citations1998J J Neil, Shelly I. Shiran +9 more
The D values primarily reflect overall brain water content and the A sigma values are more sensitive to tissue microstructure (e.g., white matter packing and myelination), which reveal information and not apparent on T1- and T2-weighted images.
Magnetic Resonance in MedicineColor schemes to represent the orientation of anisotropic tissues from diffusion tensor data: Application to white matter fiber tract mapping in the human brain
644 Citations1999Sinisa Pajevic, Carlo Pierpaoli
Directionally encoded color maps of the human brain obtained using empirical or heuristic schemes provide a simple and effective way to visualize fiber direction, useful for investigating the structural anatomy of different organs.
Magnetic Resonance in MedicineImaging cortical association tracts in the human brain using diffusion‐tensor‐based axonal tracking
561 Citations2002Susumu Mori, Walter E. Kaufmann +10 more
A reduction in brain connectivity in a patient with a childhood neurodegenerative disease (X‐linked adrenoleukodystrophy) was demonstrated, and guidelines were developed to reproducibly track these fibers in vivo.
PEDIATRICSCerebral White Matter Injury of the Premature Infant—More Common Than You Think
531 Citations2003Joseph J. Volpe
The current report of the Hammersmith group by Counsell et al,6 published elsewhere in this issue, addresses the frequency and magnetic resonance imaging (MRI) characteristics of this diffuse white matter abnormality.
NeuroImageDiffusion Tensor Imaging and Axonal Tracking in the Human Brainstem
497 Citations2001Bram Stieltjes, Walter E. Kaufmann +5 more
Diffusion tensor MRI was used to demonstrate in vivo anatomical mapping of brainstem axonal connections and reveals that each tract has a unique spatial signature in terms of water relaxation and diffusion anisotropy.
NMR in BiomedicineApplications of diffusion‐weighted and diffusion tensor MRI to white matter diseases – a review
470 Citations2002Mark A. Horsfield, Derek K. Jones
The contribution that diffusion‐weighted imaging has made to the understanding of white matter diseases is critically appraised and the quantitative nature of diffusion MRI is one of its major attractions; however, this is offset by the more advanced hardware required to collect diffusion‐ Weighted images reliably, and the more complex processing to produce quantitative parametric diffusion images.
PubMedDiffusion-tensor MR imaging of gray and white matter development during normal human brain maturation.
457 Citations2002Pratik Mukherjee, Jeffrey H Miller +7 more
Diffusion-tensor MR imaging is a powerful method for studying the process of brain development, with both scientific and clinical applications, and changes in water diffusion during maturation of central gray and white matter structures can be explained by theoretical models incorporating simple assumptions regarding the influence of brain water content and myelination.
StrokePresence and Severity of Cerebral White Matter Lesions and Hypertension, Its Treatment, and Its Control
452 Citations1996Duanping Liao, Lawton S. Cooper +5 more
The data suggest that the level of blood pressure, especially systolicBlood pressure, is related to WML, additional to the effects of categorically defined hypertension and its treatment and control status.
RadiologyNormal Brain Maturation during Childhood: Developmental Trends Characterized with Diffusion-Tensor MR Imaging
433 Citations2001Pratik Mukherjee, Jeffrey H Miller +5 more
Changes in magnitude and anisotropy of water diffusion follow stereotypical time courses during brain development that can be empirically described with multiexponential regression models, which suggests that quantitative scalar parameters derived from diffusion-tensor MR imaging may provide clinically useful developmental milestones for brain maturity.
NMR in BiomedicineDiffusion tensor imaging of normal and injured developing human brain ‐ a technical review
397 Citations2002Jeffrey J. Neil, Jeffrey H Miller +2 more
DTI offers unique insight into brain injury and maturation, and does so in a fashion that can be readily applied in a clinical setting, and appears more sensitive to disruption of white matter than any other imaging method.
Magnetic Resonance in MedicineIn vivo three-dimensional reconstruction of rat brain axonal projections by diffusion tensor imaging
385 Citations1999Rong Xue, Peter C.M. van Zijl +3 more
It is shown here that in vivo three‐dimensional reconstruction of axonal projections can be achieved using a rapid 3D high‐resolution diffusion‐weighted imaging technique combined with a recently designed fiber reconstruction algorithm.
Annals of NeurologyMorphometry of in vivo human white matter association pathways with diffusion‐weighted magnetic resonance imaging
379 Citations1997Nikos Makris, Andrew J. Worth +13 more
This method was used to map the “stem” (compact portion) of the principal association, projection, and commissural white matter pathways of the human brain in vivo, in 3 normal subjects and represents an important method for the characterization of major association pathways in the living human that are not discernible by conventional magnetic resonance imaging.
PEDIATRICSMicrostructural Brain Development After Perinatal Cerebral White Matter Injury Assessed by Diffusion Tensor Magnetic Resonance Imaging
361 Citations2001Petra S. Hüppi, Brendan P. Murphy +7 more
The ultimate impact of brain injury in the newborn should be considered as a function not only of tissue destruction, but also of impaired subsequent brain development.
NeuropathologyPeriventricular leukomalacia, inflammation and white matter lesions within the developing nervous system
336 Citations2002Payam Rezaie, Andrew Dean
Current concepts on the pathogenesis of PVL are presented and the increasing evidence for an inflammatory pathogenic component to this disorder, either resulting from hypoxic‐ischemic injury or from infection is emphasized.
Journal of Magnetic Resonance ImagingSerial quantitative diffusion tensor MRI of the premature brain: Development in newborns with and without injury
328 Citations2002Steven P. Miller, Daniel B. Vigneron +8 more
To determine the change over time of the apparent diffusion coefficient (ADC) and relative anisotropy of cerebral water in a cohort of premature newborns serially studied near birth and again near term, data are averaged over a 12-month period.
PubMedAdrenoleukodystrophy: a scoring method for brain MR observations.
325 Citations1994Daniel J. Loes, Stephen H. Hite +6 more
The adrenoleukodystrophy MR severity scoring method is a measure that can be used with standard MR images and when used in conjunction with clinical parameters, may help define better the natural history of adrenoleUKody Strophy and monitor response to developing therapies.
NeuroImageDiffusion tensor imaging with tract-based spatial statistics reveals local white matter abnormalities in preterm infants
317 Citations2007Mustafa Anjari, Latha Srinivasan +5 more
This study demonstrates that TBSS provides an observer-independent method of identifying white matter abnormalities in the preterm brain at term equivalent age in the absence of focal lesions.
Seminars in NeonatologyMechanisms of perinatal brain injury
284 Citations2000Terrie E. Inder, Joseph J. Volpe
The physiological and cellular/molecular mechanisms of brain injury in the term infant are described, followed by the mechanisms in the premature infant.
NeurologyA prospective, longitudinal diffusion tensor imaging study of brain injury in newborns
279 Citations2002Robert C. McKinstry, Jeffrey H Miller +7 more
Overall, diffusion MR may not be suitable as a gold standard for detection of brain injury during the first day after injury in newborn infants because of transient pseudonormalization of Dav.
PubMedComparing the diagnosis of white matter injury in premature newborns with serial MR imaging and transfontanel ultrasonography findings.
270 Citations2003Steven P. Miller, Camilla Ceppi Cozzio +5 more
Although ultrasonography is commonly used to screen premature neonates for white matter injury, it was not a sensitive predictor of the milder spectrum of MR imaging-defined white matter abnormalities.
BrainQuantitative diffusion tensor imaging in cerebral palsy due to periventricular white matter injury
229 Citations2005Bejoy Thomas, Maria Eyssen +5 more
The degeneration of various motor and sensory pathways, as well as deep grey matter structures, appears to be important in determining the pathophysiological mechanisms in patients with congenital PWI.
PubMedCerebral palsy: MR findings in 40 patients.
210 Citations1992C. L. Truwit, A J Barkovich +2 more
The results support a growing consensus that cerebral palsy in term infants is often the result of prenatal factors, and less commonly related to the perinatal period.
NeurologyDiffusion tensor imaging of periventricular leukomalacia shows affected sensory cortex white matter pathways
193 Citations2002Alexander H. Hoon, W. T. Lawrie +7 more
Findings suggest that the motor impairment in periventricular leukomalacia may, in part, reflect disruption of sensory connections outside classic pyramidal motor pathways.
Magnetic Resonance in MedicineAnalysis of noise effects on DTI‐based tractography using the brute‐force and multi‐ROI approach
189 Citations2004Hao Huang, Jiangyang Zhang +2 more
The hypothesis that one can increase the validity of DTI‐based tractography by adopting the BF and multi‐ROI approach, with respect to the simple one‐ ROI approach is confirmed.
PEDIATRICSQuantification of Deep Gray Matter in Preterm Infants at Term-Equivalent Age Using Manual Volumetry of 3-Tesla Magnetic Resonance Images
173 Citations2007Latha Srinivasan, Robin K. Dutta +5 more
Manual volumetry confirms that preterm infants at term-equivalent age have reduced thalamic and lentiform volumes compared with controls, most marked among infants with supratentorial lesions but also seen among those with nonfocal white matter abnormalities.
PubMedDiffusion tensor brain imaging findings at term-equivalent age may predict neurologic abnormalities in low birth weight preterm infants.
172 Citations2003Y Arzoumanian, Majid Mirmiran +6 more
The results suggest that neonatal diffusion tensor imaging may allow earlier detection of specific anatomic findings of microstructural abnormalities in infants at risk for neurologic abnormalities and disability.
Archives of Disease in Childhood Fetal & NeonatalMagnetic resonance imaging of preterm brain injury
166 Citations2003Serena J. Counsell, M A Rutherford +2 more
Physical TherapyPhysical Therapists' Perceptions of Factors Influencing the Acquisition of Motor Abilities of Children With Cerebral Palsy: Implications for Clinical Reasoning
166 Citations2002Doreen J. Bartlett, Robert J. Palisano
A consensus exercise was conducted to identify factors perceived to affect the acquisition of basic motor abilities among children with cerebral palsy from the time of diagnosis to 7 years of age that can provide foundation knowledge for decision making and research on factors that bring about change in motor ability.
American Journal of RoentgenologyMR imaging of periventricular leukomalacia in childhood
141 Citations1989Olof Flodmark, Brian A. Lupton +6 more
MR recognition of cerebral white matter abnormalities associated with periventricular leukomalacia may confirm the clinical suspicion of this diagnosis in children with spastic diplegia or quadriplegia.
Journal of Child NeurologyNeuropathologic Substrate of Cerebral Palsy
130 Citations2005Rebecca D. Folkerth
This review summarizes the classic and more recent studies of the neuropathology of human perinatal brain injury most commonly associated with cerebral palsy, for use by researchers and clinicians alike who need to analyze published animal models with respect to their fidelity to the human disorder.
Journal of Child NeurologyPharmacotherapy of Spasticity: Oral Medications and Intrathecal Baclofen
128 Citations2001Linda E. Krach
This article is a review of the sites of action, side effects, and efficacy of benzodiazepines, baclofen, dantrolene sodium, alpha2-adrenergic agonists, and gabapentin.
RadiologyPeriventricular leukomalacia: radiologic diagnosis.
107 Citations1987Olof Flodmark, E. H. Roland +2 more
Computed tomography scans of the brain demonstrated the following characteristic abnormalities: reduction in quantity of periventricular white matter, particularly at the trigone, deep and prominent sulci that abutted the ventricles without interposedwhite matter, and ventriculomegaly with irregular outline of the lateral ventricle.
Journal of Magnetic Resonance ImagingDTI‐based three‐dimensional tractography detects differences in the pyramidal tracts of infants and children with congenital hemiparesis
106 Citations2003Orit A. Glenn, Roland G. Henry +5 more
To test the hypothesis that there is greater asymmetry in diffusion properties between right and left pyramidal tracts in patients with congenital hemiparesis than in Patients with normal motor function, a diffusion-gauging experiment is conducted.
Brain PathologyInterferon‐γ Expression in Periventricular Leukomalacia in the Human Brain
103 Citations2004Rebecca D. Folkerth, Rachael J. Keefe +4 more
In PVL, IFN-gamma produced by macrophages and reactive astrocytes may play a role in cytokine-induced toxicity to premyelinating oligodendrocyte cells as part of a cytokine response stimulated by ischemia and/or infection.
Journal of Child NeurologyFrequency and Nature of Cerebellar Injury in the Extremely Premature Survivor with Cerebral Palsy
98 Citations2005Stanley D. Johnsen, John B. Bodensteiner +1 more
From a larger collection of children with known cerebellar injury and cerebral palsy who had a history of being extremely premature, it was found that 35 of 47 patients had prominent injury to the inferior cerebellum, suggesting infarction, whereas the remainder demonstrated varying degrees of Cerebellar atrophy with or without asymmetry.
RadiologyEnd-stage periventricular leukomalacia: MR evaluation.
91 Citations1988L L Baker, David K. Stevenson +1 more
Assessment of magnetic resonance imaging in evaluation of end-stage periventricular leukomalacia in six children in whom PVL had been documented by neurologic ultrasonography during the neonatal period found it useful in detecting subtle forms of PVL in cases in which neurologic damage was subclinical.
Seminars in NeonatologyMagnetic resonance techniques in the evaluation of the perinatal brain: recent advances and future directions
86 Citations2001Petra S. Hüppi, Terrie E. Inder
This review will focus on the application of different MR techniques including the conventional structural MR imaging techniques and the more advanced MR techniques, such as the quantitative morphometric MR methods, the diffusion weighted MR Techniques, the functional MR techniques and MR spectroscopy in the study of the fetal and newborn brain.
PubMedAssessment of the deep gray nuclei in holoprosencephaly.
85 Citations2001Erin M. Simon, Robert F. Hevner +6 more
The hypothalamus and caudate nuclei are the most severely affected structures in holoprosencephaly, and the mesencephalic structures are more commonly involved than previously thought in this "prosencephalics disorder."
Journal of Pediatric OrthopaedicsLong-term follow-up of surgery for equinovarus foot deformity in children with cerebral palsy.
60 Citations2002Chia-Hsieh Chang, Juan P. Albarracin +2 more
NeuropediatricsCorrelation of Corpus Callosal Morphometry with Cognitive and Motor Function in Periventricular Leukomalacia
46 Citations2003Christos Davatzikos, A. Barzi +3 more
Clinics in PerinatologyMagnetic Resonance Techniques in the Evaluation of the Newborn Brain
46 Citations1997Petra S. Hüppi, Patrick D. Barnes
MR imaging provides unequaled sensitivity as compared with US or CT scanning for evaluating developmental changes and pathologic processes in the newborn brain and has further opened the possibility of studying the metabolic mechanisms that define the pathophysiologic events taking place in neonatal brain injury.
Pediatric NeurologyCharacteristic neuropathology and plasticity in periventricular leukomalacia
45 Citations2001Yumi Okoshi, Masayuki Itoh +1 more
The brains of extremely low-birth-weight infants with periventricular leukomalacia, who survived for more than 30 days, were examined by means of neuropathologic and immunohistochemical methods, and nestin-positive astrocytes, and neurons increased around the lesions, suggesting the plasticity of the brains.
Clinical RadiologyPotential of diffusion tensor MRI in the assessment of periventricular leukomalacia
38 Citations2006Guoguang Fan, Bing Yu +3 more
DTI can provide more information for understanding the pathophysiology of motor disability and associated sensory handicap in PVL and there were no statistically significant differences of the ICAL, ML, MCP, and brainstem CST when analysed using a two-tailed Student's t-test for paired data.
American Journal of Physical Medicine & RehabilitationDiffusion Tensor Magnetic Resonance Imaging of Microstructural Abnormalities in Children with Brain Injury
30 Citations2003Zee Ihn Lee, Woo Mok Byun +4 more
Two pediatric cases demonstrating that diffusion tensor imaging is more efficient at revealing microstructural abnormalities of the brain than conventional magnetic resonance imaging are presented because it enables measurements of the directionality and integrity of white matter fiber tracts.
NeuropediatricsFollow-Up of Children with Cerebral Palsy after Selective Posterior Rhizotomy with Intensive Physiotherapy or Physiotherapy Alone
28 Citations2003Hanna Mäenpää, T Salokorpi +5 more
It is concluded that this comparative study failed to demonstrate any additional effect of SPR on motor development of children with spastic CP, but SPR may contribute to a resumption of motor development in children with arrested motor development despite vigorous conservative therapy.
Journal of Child NeurologyNeuroimaging in Spasticity and Movement Disorders
25 Citations2003Alexander H. Hoon, Karin M. Belsito +1 more
This review focuses on imaging studies that can be effectively used in at-risk infants and in children with spasticity and movement disorders to refine diagnosis and guide therapeutic interventions.
NeonatologyAdvanced Magnetic Resonance Imaging Techniques in Perinatal Brain Injury<sup>1</sup>
15 Citations2001Petra S. Hüppi, Maurizio Amato
New diagnostic tools, such as quantitative three-dimensional magnetic resonance (MR) imaging, diffusion-weighted MR imaging and proton MR spectroscopy, are presented in this review article that allow to assess brain development, detect early brain injury and monitor effects of perinatal brain injury on subsequent brain development and brain plasticity.
