Prostaglandin formation in bacteria : A reevaluation
ProstaglandinsPublished 1 March 1981
Egīls Gulbis, N. Galand, J.E. Dumont, E. Schell‐Frederick
Citations12
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TL;DR
It is reported here that production and release of PGE2 do not occur in common bacteria and the presence of P GE2 like material in some but not all isolates of Propionibacterium acnes is confirmed.
Abstract
We report here that production and release of PGE2 do not occur in common bacteria. The apparent production in the presence of arachidonic acid, previously reported (1) may be explained by PGE2 contamination and autooxidation of the AA used. The presence of PGE2 like material in some but not all isolates of Propionibacterium acnes is confirmed.
Keywords
Materials ScienceMedicine
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The presence of prostaglandin-like substances inPropionibacterium acnes is reported for the first time.
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16 Citations1979Egīls Gulbis, Alejandra Marión +2 more
It is reported here that intact Gram positive and Gram negative bacteria, in the presence of exogenous arachidonic acid, produce and release PGE2 and PGF2 alpha into the medium as measured by radioimmunoassay.
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The results of this study suggest that the interference produced by the presence of NEFA in the measurement of prostaglandsin from certain physiological fluids may be avoided if the prostaglandins are not extracted prior to radioimmunoassay.
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14 Citations1979Lars Hellgren, Gunnar Selstam +1 more
The prostaglandin-like substances (PLS) fromPropionibacterium acnes increased the ovarian tissue levels of cyclic AMP (cAMP) approximately 2-fold, and since it is unlikely that other known stimulators of the ovarian cAMP system can be present in the bacterial lipid fraction, these experiments give further evidence in favour of the occurrence of PLS in P. acnes.
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The bioassay experiments support the concept that prostaglandin-like substances (PLS) occur in P. acnes, but the effect of PLS was different from that of PGF2α and PGI2 but similar, although not identical, to that of arachidonic acid and PGE2.
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Analysis of prostaglandin-like substances isolated from P. acnes demonstrated that PLS were not identical with PGE2, which supports a concept of PLS as a potential mediator of the inflammatory process in acne vulgaris.