Cathepsin B in osteoarthritis: cytochemical and histochemical analysis of human femoral head cartilage.
Annals of the Rheumatic DiseasesPublished 1 April 1995Open access
Antonio Baici, A Lang, Dorothy Hörler, R Kissling, C. Merlin
Citations77
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TL;DR
The presence and the particular distribution of active cathepsin B in OA cartilage at 'more involved' sites suggest a pathological role for this enzyme in sustaining and perpetuating cartilage degradation.
Abstract
The presence and the particular distribution of active cathepsin B in OA cartilage at 'more involved' sites suggest a pathological role for this enzyme in sustaining and perpetuating cartilage degradation. While other stimuli may also be responsible for cathepsin B expression in OA chondrocytes, the similarity with artificially modulated cells indicates fibroblastic metaplasia as a plausible mechanism.
Keywords
MedicineBiochemistry, Genetics and Molecular Biology
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