Suicide Research
Annals of the New York Academy of SciencesPublished 1 December 1997Open access
David M. Stoff, J. John Mann
Citations27
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TL;DR
This volume of the Annals describes the most promising suicide research findings over the last decade since publication of a previous comprehensive volume on suicide research.
Abstract
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Keywords
Psychology
Journal of Experimental Psychology GeneralLearned helplessness: Theory and evidence.
2,322 Citations1976Steven F. Maier, Martin E. P. Seligman
The learned helplessness hypothesis is proposed, which argues that when events are uncontrollable the organism learns that its behavior and outcomes are independent, and that this learning produces the motivational, cognitive, and emotional effects of uncontrollabi lity.
Archives of Neurology And PsychiatryPRELIMINARY ANALYSIS OF FUNCTIONS OF THE TEMPORAL LOBES IN MONKEYS
1,697 Citations1939Heinrich Klüver
The results were primarily based on an analysis of the behavioral symptoms of a female rhesus monkey which had been studied for a period of four months following the operations, and the type of disturbance analyzed seemed to be similar to the "associative mind blindness" of Lissauer.
Archives of General Psychiatry5-HIAA in the Cerebrospinal Fluid
1,432 Citations1976Marie Åsberg
Patients in the low 5-HIAA mode (below 15 ng/ml) attempted suicide significantly more often than those in the high mode, and they used more violent means.
PsychopharmacologyThe validity of animal models of depression
1,389 Citations1984Paul Willner
The models with the highest overall validity are the intracranial self-stimulation, chronic stress and learned helplessness models in rats, and the primate separation model.
Behavioral and Brain SciencesReconciling the role of central serotonin neurons in human and animal behavior
1,012 Citations1986Philippe Soubrié
Whether anxiety reduction or increased impulsivity is more likely to account for animal behavioral changes associated with decreased serotonergic transmission is investigated, as well as the effects of manipulating central serotonin in experimental anxiety paradigms in animals (punishment, extinction, novelty).
Science"Serotonin Depression"—A Biochemical Subgroup Within the Affective Disorders?
679 Citations1976Marie Åsberg, Peter Thorén +3 more
There was a significant correlation between the concnetration of 5-HIAA and severity of depression in the lower, but not in the upper, mode, which suggests the existence of a biochemical subgroup of depressive disorder, characterized by a disturbance of serotonin turnover.
Archives of General PsychiatryReduced Corticotropin Releasing Factor Binding Sites in the Frontal Cortex of Suicide Victims
555 Citations1988Charles B. Nemeroff
There was a marked (23%) reduction in the number of CRF binding sites in the frontal cortex of the suicide victims compared with the controls, which is consistent with the hypothesis that CRF is hypersecreted in depression.
Psychosomatic MedicineOn the Phenomenon of Sudden Death in Animals and Man
390 Citations1957Curt P. Richter
In this instance as in many others, the ideas of Walter Cannon opened up a new area of interesting, exciting research.
Psychosomatic MedicineDepressed Mood and Other Psychiatric Manifestations of Cushingʼs Syndrome: Relationship to Hormone Levels
289 Citations1981Monica N. Starkman, D.E. Schteingart +1 more
A statistically significant relationship was found between the overall psychiatric disability rating and cortisol and ACTH level and low ACTH levels were significantly associated with milder rather than pronounced depressed mood.
Archives of Neurology And PsychiatryNEUROPSYCHIATRIC ASPECTS OF CUSHING'S SYNDROME
146 Citations1952W. H. Trethowan
It now seems clear that, whatever additional pathological changes are uncovered at autopsy, the clinical picture of both Cushed's disease and Cushing's syndrome can be regarded as the result of adrenocortical hyperfunction, whether neoplastic or hyperplastic in anatomical expression.
Archives of General PsychiatryPossibility of a Biochemical Test for Suicidal Potential
124 Citations1965William E. Bunney
The question is posed: Could a biochemical test aid in the prediction of suicidal intent in depressed patients?
Journal of Affective DisordersAmine metabolites and neuroendocrine responses related to depression and suicide
123 Citations1983Csaba M. Bánki, Mihály Arató
Suicidal patients, and in particular those who used violent methods, tended to have lower 5-HIAA, but not HVA, in their CSF; they also more often had non-suppression of cortisol after dexamethasone, and neither suicide nor postdexamethAsone cortisol levels showed any relation to maximal TSH changes.
Archives of General PsychiatryCortisol in the CSF of Depressed and Suicidal Patients
116 Citations1980Lil Träskman
The factors that contributed most to the variance in CSF cortisol levels were a diagnosis of depression, height, and important life changes during the six months preceding the investigation.
American Journal of PsychiatrySuicide and the dexamethasone suppression test in unipolar depression
110 Citations1981William Coryell, Michael A. Schlesser
The authors suggest that hypothalamic-pituitary-adrenal dysfunction is associated with a type of primary depressive illness that is more likely to involve suicide than are other types.
Archives of General PsychiatryFurther Evaluation of Urinary 17-Hydroxycorticosteroids in Suicidal Patients
106 Citations1969William E. Bunney
American Journal of PsychiatryThe dexamethasone suppression test in suicidal patients with unipolar depression
105 Citations1983Steven D. Targum, Lee A. Rosén +1 more
Findings suggest that the tendency of endogenously depressed patients to attempt suicide is exacerbated by an underlying neurobiological disorder reflected by limbic-hypothalamic dysregulation and that depressed suicidal patients with abnormal DSTs represent a high-risk group for recurrence of suicidal behavior.
Suicide and Life-Threatening BehaviorDysfunctional Attitudes and Suicidal Ideation in Psychiatric Outpatients
72 Citations1993Aaron T. Beck, Robert A. Steer +1 more
The contributions of sets of dysfunctional attitudes for identifying and explaining suicidal ideation were overshadowed by a history of a past suicide attempt and hopelessness.
Elsevier eBooksSUICIDE, NEUROENDOCRINE DYSFUNCTION AND CSF 5-HIAA CONCENTRATIONS IN DEPRESSION
59 Citations1981Bernard J. Carroll, John F. Greden +1 more
The neuroendocrine disturbance and the neurotransmitter disturbance appear to be unrelated biochemical markers in depressed patients.
Journal of MammalogyThe Self-Mutilation of a Male Macacus Rhesus Monkey
53 Citations1928O. L. Tinklepaugh
PubMedThe plasma level of cortisol as a predictor of suicide.
41 Citations1974George Krieger
If a suicidal risk patient has a plasma cortisol level above 20 ug%, in the absence of other possible causes for such a high level, it is recommended he be recognized as having a high potential for suicide, be provided with more protective precautions, more frequent contacts with his therapist and prolonged after-care.
European Journal of PharmacologyAutomutilation induced by clonidine in mice
36 Citations1975Abdul Razzak, Michihiro Fujiwara +1 more
Clonidine (2-(2,6-dichlorophenylamino)-2-imidazoline hydrochloride, St155, Catapres), after administration of a single large dose, was found to induce automutilation in mice housed individually in the absence of objects to bite.
Advances in experimental medicine and biologyNeurochemical and Electrophysiological Events Underlying Stress-Induced Depression in an Animal Model
35 Citations1988Jay M. Weiss, Peter E. Simson
Findings from electrophysiological measurement of LC activity support the view that the LC is involved in stress-induced depression, and are consistent with a proposed mechanism that attributes behavioral disturbance in the model to disinhibition of LC neurons arising from subnormal activation of inhibitory alpha-2 receptors.
The American Historical ReviewSelf-Destruction in the Promised Land: A Psychocultural Biology of American Suicide.
29 Citations1990Carole Haber, Howard I. Kushner
Archives of General PsychiatryFailure of the Urinary Test for Suicide Potential
27 Citations1969Bernard Lévy
Urine 17-hydroxycorticosteroid determinations in a group of 36 depressed inpatients showed high mean urinary 17OHCS determinations, and patients had relatively low clinical ratings of suicidal behavior making such a test of great practical value.