Depolarization- and Ionophore-Induced Release of Octacosa Somatostatin from Stalk Median Eminence Synaptosomes
SciencePublished 21 August 1981
C. F. Kewley, Robert P. Millar, M C Berman, Andrew V. Schally
Citations54
SJR quartileQ1
SJR score10.42
SNIP6.62
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TL;DR
Octacosa somatostatin appears to be secreted into the hypothalamic-hypophyseal system, supporting the concept of a role for this peptide in regulating pituitary hormone secretion.
Abstract
Species of somatostatin of higher molecular weight were present in the nerve terminals (synaptosomes) of ovine stalk median eminences and were released by depolarizing stimuli. One of these species was identified as the biologically active molecule octacosa somatostatin. Octacosa somatostatin appears therefore to be secreted into the hypothalamic-hypophyseal system, supporting the concept of a role for this peptide in regulating pituitary hormone secretion.
Keywords
MedicineNeuroscience
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