Concentrations of the water-soluble vitamins thiamin, ascorbic acid, and folic acid in serum and cerebrospinal fluid of healthy individuals
American Journal of Clinical NutritionPublished 1 September 1992
Chantal Tallaksen, Thomas Bøhmer, H. Bell
Citations55
SJR quartileQ1
SJR score2.11
SNIP1.75
Generate an AI Snapshot to get a quick, structured summary of this paper.
Study Snapshot
ObjectiveStudy objective
MethodsResearch methodology
PopulationPopulation studied
Sample sizeSample sizes
OutcomesStudy outcomes here
ResultsStudy results comes here
LimitationsResearch study limitations comes here
A concise AI-generated summary of the paper will appear here once you click Generate AI Snapshot.
TL;DR
The results support the existence of a saturated transport mechanism of water-soluble vitamins from serum into CSF for thiamin monophosphate, ascorbic acid, and folic acid, however, low CSF concentrations are correlated with low serum concentrations for the three vitamins.
Abstract
Thiamin, thiamin monophosphate, ascorbic acid, and folic acid were determined in serum and cerebrospinal fluid (CSF) in 31 outpatients who underwent a myelography because of back-pain. All subjects were otherwise healthy. The CSF concentration (mean +/- SD) was 8.6 +/- 3.9 nmol thiamin/L, 16.9 +/- 8.3 nmol thiamin monophosphate/L, 133 +/- 58.8 mumol ascorbic acid/L, and 44.9 +/- 13.2 nmol folic acid/L. The CSF-serum ratio was 2.1 +/- 0.8 for thiamin, 8.3 +/- 4.3 for thiamin monophosphate, 3.0 +/- 1.4 for ascorbic acid, and 3.3 +/- 0.8 for folic acid; the amount in CSF was significantly higher than in serum for each compound. These results support the existence of a saturated transport mechanism of water-soluble vitamins from serum into CSF for thiamin monophosphate, ascorbic acid, and folic acid. However, low CSF concentrations are correlated with low serum concentrations for the three vitamins. High serum concentrations should therefore be advocated to ensure high CSF concentrations.
Keywords
Medicine
Interpretation and Uses of Medical Statistics
560 Citations2000Leslie Daly, Geoffrey J. Bourke
This work describes data -- A Single Variable, a single Variable: Associations between Two Quantitative Variables: Regression and Correlation, and Hypothesis Testing: General Principles and One--sample Tests for Means, Proportions, Counts and Rates.
Biochemical MedicineA rapid micromethod for the determination of ascorbic acid in plasma and tissues
376 Citations1974Vincent G. Zannoni, M. Lynch +2 more
A rapid simple micromethod for the determination of l -ascorbic acid in plasma and other biological tissues using orthophosphoric acid and ferric iron is presented and can be used to accurately determine 0.1 μg of the vitamin in samples of plasma andOther biological tissues.
New England Journal of MedicineVitamin Homeostasis in the Central Nervous System
170 Citations1977Howard L. Bleich, Emily S. Boro +1 more
Several groups of investigators have suggested that pharmacologic doses of certain water-soluble vitamins, including vitamins B6, B12 and C and niacin, may be useful in the treatment of schizophrenic patients.
American Journal of Physiology-Legacy ContentFolate transport in the central nervous system
113 Citations1975Reynold Spector, AV Lorenzo
The results suggest that the transport system for mehtyltetrahydrofolic acid, which is about half-saturated at normal plasma concentrations, helps maintain the cerebrospinal fluid and probably brain methyltetraydro folic acid concentrations within relatively narrow limits.
The American Journal of MedicineDrugs, toxins and dietary amino acids affecting vitamin B12 or folic acid absorption or utilization
97 Citations1970Samuel Waxman, Joséj. Corcino +1 more
Comparison of short-term cultures of human bone marrow with similar cultures of pathogenic microorganisms or neoplastic cells can measure the relative effects of new or suspected FAA on folate-dependent steps in DNA synthesis in vitro and may make it possible to predict use in vivo.
Journal of Neurology Neurosurgery & PsychiatryVitamin B12 and folate concentrations in serum and cerebrospinal fluid of neurological patients with special reference to multiple sclerosis and dementia.
91 Citations1990T Q Nijst, Ron A. Wevers +3 more
Serum and CSF vitamin B12 concentrations showed a positive correlation and two patients had very high serum B12 and low-normal CSF concentrations which could be explained by a blood-brain barrier transport defect.
Journal of Chromatography B Biomedical Sciences and ApplicationsConcomitant determination of thiamin and its phosphate esters in human blood and serum by high-performance liquid chromatography
80 Citations1991Chantal Tallaksen, Thomas Bøhmer +2 more
A high-performance liquid chromatographic method for the simultaneous determination ofThiamin and thiamin phosphate esters in human blood or serum has been developed and the detection limit is 13-16 fmol.
American Journal of Physiology-Legacy ContentThiamine transport in the central nervous system
56 Citations1976Reynold Spector
The results were interpreted as showing that the entry of total thiamine into the brain and CSF from blood is regulated by a saturable transport system, and that the locus of this system may be, in part, in the choroid plexus.
Experimental NeurologyPenetration of ascorbic acid from cerebrospinal fluid into brain
51 Citations1981Reynold Spector
The direct demonstration that [ 14 C]ascorbic acid can penetrate from the CSF into the depths of the brain substance is consistent with the view that ascorbic acid enters brain from blood primarily via theCSF.
Biological PsychiatryConcentration gradients for HVA, 5-HIAA, ascorbic acid, and uric acid in cerebrospinal fluid
41 Citations1990I Degrell, Erzsébet Nagy
Findings indicate that extrapolations to cisternal neurotransmitter metabolite concentration from lumbar measures are unwarranted for HVA, but not for 5-HIAA.
British Journal Of NutritionThe B-vitamins in malnutrition with alcoholism
40 Citations1976D. K. Dastur, N. Santhadevi +5 more
The B-vitamin status of fifty-nine patients, mainly from the lower socio-economic classes in Bombay, with a history of chronic malnutrition, and of alcoholism, was studied before and during treatment, and in relation to their clinical, especially neurological, condition.
Cellular and Molecular Life SciencesMonophosphate, the only phosphoric ester of thiamin in the cerebro-spinal fluid
35 Citations1981Guido Rindi, Cesare Patrini +1 more
With a specific and sensitive electrophoretic-fluorometric method, thiamin was found in the cerebro-spinal fluid of different mammals both in free and phosphorylated form, monophosphate being the onlyThiamin phosphoric ester.
PubMedEffects of anticonvulsant treatment and low levels of folate and thiamine on amine metabolites in cerebrospinal fluid.
31 Citations1991M.I. Botez, Simon N. Young
American Journal of Clinical NutritionAge-dependent changes in thiamin concentrations in whole blood and cerebrospinal fluid in infants and children
30 Citations1991DT Wyatt, D Nelson +1 more
Changes in whole blood and CSF occurred independently and probably represent metabolic and neurological maturation of the infant and age-specific norms should be used for determining the thiamin status in infancy.
American Journal of Clinical NutritionAbsorption and passage of fat- and water-soluble thiamin derivatives into erythrocytes and cerebrospinal fluid of man
28 Citations1974Herman Baker, Allan D. Thomson +2 more
Orally administered allithiamin vitamers are recommended for prophylaxis and treatment of thiamin deficits because they have the same biological properties as parenterally administered water-soluble thiamins.
Archives of NeurologyThiamin Monophosphate in the CSF of Patients With Amyotrophic Lateral Sclerosis
18 Citations1982M. Poloni, Cesare Patrini +2 more
The T/TMP ratio could be taken as an index of the impairment of neuronal protein synthesis in ALS.
BrainEFFECTS OF ANTICONVULSANT TREATMENT AND LOW LEVELS OF FOLATE AND THIAMINE ON AMINE METABOLITES IN CEREBROSPINAL FLUID
17 Citations1991M.I. Botez, Simon N. Young
NeurosurgeryCerebrospinal Fluid Ascorbic Acid Levels in Neurological Disorders
15 Citations1984Ricardo H. Brau, Sixto García-Castiñeiras +1 more
The hypothesis of free radical damage to the central nervous system after certain types of injury (trauma, ischemia, and tumors) may provide a satisfactory explanation for the findings of this work.
Journal of Neurology Neurosurgery & PsychiatryThiamine deficiency and cerebrospinal fluid 5-hydroxyindoleacetic acid: a preliminary study.
15 Citations1982M.I. Botez, Simon N. Young +2 more
In three out of five patients with low cerebrospinal fluid thiamine concentrations, the 5-hydroxyindoleacetic acid (5HIAA) values also were low; in those patients with initially low CSF 5 HIAA, thiamines treatment increased 5HiaA markedly.
Canadian Journal of Neurological Sciences / Journal Canadien des Sciences NeurologiquesCerebrospinal Fluid and Blood Thiamine Concentrations in Phenytoin-Treated Epileptics
12 Citations1982M.I. Botez, Claude Joyal +2 more
Thiamine and folate levels in blood and cerebrospinal fluid (CSF) were determined by microbiological assays in 23 control subjects and 11 phenytoin-treated epileptics and there was no significant difference between the two groups for serum and CSF folates.
Drug and Alcohol DependenceFolic acid in serum and cerebrospinal fluid of chronic alcoholics and methamphetamine addicts
7 Citations1981Yoichi Nakazawa, Toshito Yokoyama +5 more
From these results, a mechanism underlying the development of symptoms of physical dependence such as DT was discussed in relation to the CSF FA.
Journal of the Neurological SciencesCerebrospinal fluid folate and cobalamin levels in febrile convulsion
4 Citations1985Bola O.A. Osifo, F.A. Lukanmbi +1 more
There is an effective blood-brain barrier system for folate even when serum folate levels are higher than normal and there is also a definite decrease in serum cobalamin during pyrexia but this decrease is more apparent in the convulsing state.