The right weight: body fat, menarche and fertility
Proceedings of The Nutrition SocietyPublished 1 March 1994Open access
Rose E. Frisch
Citations125
SJR quartileQ1
SJR score1.94
SNIP1.80
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Medicine
Archives of NeurologyHandbook of Physiology.
10,386 Citations1960F. Plum
This is the first volume of the proposed many-sectioned "Handbook" in which the American Physiological Society intends to present comprehensively the entire field of physiology.
JAMAPhysical Fitness and All-Cause Mortality
2,570 Citations1989Steven N. Blair
Higher levels of physical fitness appear to delay all-cause mortality primarily due to lowered rates of cardiovascular disease and cancer, and lower mortality rates in higher fitness categories also were seen for cardiovascular Disease and cancer of combined sites.
Clinical gynecologic endocrinology and infertility
2,115 Citations1983Marc A. Fritz, Leon Speroff
J. Murray eBooksThe variation of animals and plants under domestication /
1,723 Citations1905Charles Darwin
ScienceMenstrual Cycles: Fatness as a Determinant of Minimum Weight for Height Necessary for Their Maintenance or Onset
1,424 Citations1974Rose E. Frisch, Janet W. McArthur
The data suggest that a minimum level of stored, easily mobilized energy is necessary for ovulation and menstrual cycles in the human female.
The Journal of Clinical Endocrinology & MetabolismThe Effects of Exercise on Pubertal Progression and Reproductive Function in Girls*
616 Citations1980Michelle P. Warren
Energy drain may have an important modulatory effect on the hypothalamic pituitary set point at puberty and, in combination with low body weight, may prolong the prepubertal state and induce amenorrhea.
JAMADelayed Menarche and Amenorrhea of College Athletes in Relation to Age of Onset of Training
458 Citations1981Rose E. Frisch
Training increased the incidence of oligomenorrhea and amenorrhea among both premenarche- and postmenarches-trained athletes, and metabolic and hormonal changes consequent to an increased lean/fat ratio may explain these findings.
New England Journal of MedicineEvidence for a Secular Trend in Age of Menarche
455 Citations1982Grace Wyshak, Rose E. Frisch
Data is presented documenting a secular trend toward an earlier age of menarche in Europe and the United States in the past century and there has been recent controversy on whether such a change has taken place.
The Journal of PhysiologyBody weight and food intake as initiating factors for puberty in the rat
441 Citations1963G. C. Kennedy, J. Mitra
The Journal of Clinical Endocrinology & MetabolismClinical and Hormonal Characteristics of Obese Amenorrheic Hyperandrogenic Women Before and After Weight Loss*
438 Citations1989Renato Pasquali, D. Antenucci +7 more
It is concluded that weight loss is beneficial in all obese hyper androgenic women regardless of the presence of polycystic ovaries, the degree of hyperandrogenism, and the degree and distribution of obesity.
Archives of Disease in ChildhoodHeight and weight at menarche and a hypothesis of menarche
435 Citations1971R E Frisch, Roger Revelle
Early and late menarcheal girls gain the same amount of height and weight in the interval from the initiation of the adolescent spurt to menarches, though late maturers grow at slower rates during the spurt.
Cambridge University Press eBooksThe Variation of Animals and Plants under Domestication
432 Citations2010Charles Darwin
The reasons which induce me to believe that all organic beings occasionally cross, though perhaps in some cases only at long intervals of time, are explained.
New England Journal of MedicineDelayed Menarche and Amenorrhea in Ballet Dancers
425 Citations1980Rose E. Frisch, Grace Wyshak +1 more
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389 Citations1974ROBERT M. BOYAR, Jonathan L. Katz +5 more
ScienceDoes Malnutrition Affect Fecundity? A Summary of Evidence
366 Citations1980John Bongaarts
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British Journal of CancerLower prevalence of breast cancer and cancers of the reproductive system among former college athletes compared to non-athletes
328 Citations1985R E Frisch, Grace Wyshak +8 more
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Biological reviews/Biological reviews of the Cambridge Philosophical SocietyBODY FAT, PUBERTY AND FERTILITY
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Fat is the most labile body tissue; it reflects environmental changes more rapidly than other tissues of the body; it is a neat mechanism for relating rates of growth, nutrition and energy outputs to the energy requirements for reproduction.
New England Journal of MedicineHypothalamic Dysfunction in Secondary Amenorrhea Associated with Simple Weight Loss
314 Citations1977Robert A. Vigersky, Arnold E. Andersen +2 more
It is concluded that hypothalamic dysfunction may be caused by weight loss per se and not related to anorexia nervosa.
The Journal of Clinical Endocrinology & MetabolismAromatization of Androgens by Human Abdominal and Breast Fat Tissue1
313 Citations1975A. Nimrod, Kenneth J. Ryan
The results indicate a possible role of adipose tissue as a significant extra-gonadal source of estrogens in human abdominal, breast and axillary fat and testosterone was found to be aromatized as actively as androstenedione.
PubMedThe association of obesity with infertility and related menstural abnormalities in women.
309 Citations1979Arthur J. Hartz, Peter N. Barboriak +3 more
Findings showing evidence of abnormal ovulation, menstrual abnormalities and excess hair growth in obese women may be explained by the recent studies of others demonstrating an association between obesity and hormonal imbalances.
Obstetrics and GynecologyMenstrual Dysfunction in Distance Runners
302 Citations1979Edwin Dale, Detlef H. Gerlach +1 more
It is concluded that menstrual dysfunction in distance runners is a real phenomenon and presumably this is related to decreased percentage of body fat and/or minimal ovarian function secondary to diminished hypothalamic or pituitary hormone secretion.
JAMAReduced Serum Testosterone and Prolactin Levels in Male Distance Runners
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The mean levels of total and nonspecifically bound testosterone as well as prolactin were significantly lower than in controls, although levels remained within the physiological range.
The Journal of Clinical Endocrinology & MetabolismINFLUENCE OF BODY WEIGHT ON ESTRADIOL METABOLISM IN YOUNG WOMEN
230 Citations1975Jack Fishman, ROBERT M. BOYAR +1 more
New England Journal of MedicineDecreased Hypothalamic Gonadotropin-Releasing Hormone Secretion in Male Marathon Runners
227 Citations1986Susan E. MacConnie, Ariel L. Barkan +3 more
American Journal of Obstetrics and GynecologyExercise-associated amenorrhea: A distinct entity?
211 Citations1981Barbara Schwartz, David C. Cumming +4 more
Obstetrical & Gynecological SurveyWEIGHT RELATIONSHIPS IN PREGNANCY
209 Citations1968Nicholson J. Eastman, Esther C. Jackson
Social BiologyDemographic implications of the biological determinants of female fecundity
166 Citations1975Rose E. Frisch
American Journal of Clinical NutritionThe effect of improved nutrition on plasma prolactin concentrations and postpartum infertility in lactating Gambian women
157 Citations1984P. G. Lunn, Steve Austin +2 more
Dietary improvement during lactation alone resulted in these critical prolactin concentrations being reached 21 wk earlier than in nonsupplemented counterparts, while those receiving the extra food in both pregnancy and lactation showed a 35-wk shortening of postpartum amenorrhea and infertility.
PubMedAge at menarche and selected menstrual characteristics in athletes at different competitive levels and in different sports.
152 Citations1978Robert M. Malina, Waneen W. Spirduso +2 more
Ages at menarche in 110 non-athletes, 59 high school atjletes, 53 college athletes, and 18 olympic volleyball candidates were determined through interview and none of the chi square values comparing the three groups was significant.
EndocrinologyImpact of Continuously Administered Catechol Estrogens on Uterine Growth and Luteinizing Hormone Secretion*
150 Citations1979Charles Martucci, Jack Fishman
Binding studies of the test and other related estrogens to the uterine cytosol estradiol receptor showed that their relative binding affinities in many instances did not correlate with their biological activities.
Scientific AmericanFatness and Fertility
147 Citations1988Rose E. Frisch
Evidence is presented that a woman must store a threshold or minimum amount of body fat in order to be able to reproduce and the effects of dieting and exercise on fecundity are examined.
Palgrave Macmillan UK eBooksFertility in Traditional Societies
146 Citations1988Kenneth L. Campbell, James W. Wood
Proceedings of the National Academy of SciencesBody weight and food intake at early estrus of rats on a high-fat diet.
146 Citations1975R E Frisch, D.M. Hegsted +1 more
The findings support Kennedy's hypotheses that a food intake signal, now further defined as caloric intake/100 g of body weight, is a signal for puberty, and are in accord with the hypothesis that a critical body composition of fatness is essential for estrus in the rat, as in the human female.
Journal of Steroid BiochemistryThe interconversion and aromatization of androgens by human adipose tissue
144 Citations1979E. Perel, D.W. Killinger
The studies demonstrate the interconversion of androgens in adipose tissue and emphasize that the net effect of a gonadal steroid acting on a peripheral tissue may depend on the nature of the metabolites formed in that tissue.
Perspectives in biology and medicineFatness, Menarche, and Female Fertility
141 Citations1985Rose E. Frisch
It is hypothesized that a particular ratio of fat to lean mass is required for menarche and the maintenance of regular menstrual cycles and suggests that the secular trend toward earlier age atMenarche reflects earlier attainment of critical weight as a result of improved nutrition and child care.
The Journal of Clinical Endocrinology & MetabolismThe Significance of Weight Loss in the Evaluation of Pituitary Response to LH-RH in Women with Secondary Amenorrhea1
134 Citations1975Michelle P. Warren, R Jewelewicz +4 more
Women with weight loss were found to be unresponsive to LH-RH when severely underweight and FSH responsiveness returned in a linear fashion as weight gain occurred and was not related to estrogen levels.
The Journal of Clinical Endocrinology & MetabolismEffects of Obesity on Estradiol Metabolism: Decreased Formation of Nonuterotropic Metabolites*
131 Citations1983Jill Schneider, H. Leon Bradlow +4 more
The Journal of Agricultural ScienceEffect of flushing on reproductive performance of ewes
122 Citations1966I. E. Coop
Eight flushing experiments were conducted with grazing sheep over a 4-year period, the responses being measured at lambing, to separate, identify and measure the two components postulated as comprising the flushing response.
International Journal of Gynecology & ObstetricsRisk of ovulatory infertility in relation to body weight
116 Citations1989Beverly B. Green, Noel S. Weiss +1 more
BMJOutcome of pregnancy in underweight women after spontaneous and induced ovulation
115 Citations1988Zephne M. van der Spuy, Philip Steer +3 more
The Journal of Clinical Endocrinology & MetabolismDEFECTS IN PULSATILE LH RELEASE IN NORMALLY MENSTRUATING RUNNERS
115 Citations1985David C. Cumming, M.M. Vickovic +2 more
Data suggest that there is a central inhibition of the hypothalamic-pituitary-gonadal axis in eumenorrheic runners, and this results suggest that intense physical exercise may be abnormal in a majority of women with a heavy training load.
The Journal of Clinical Endocrinology & MetabolismThe Effect of a Low Fat Diet on Estrogen Metabolism*
114 Citations1987Christopher Longcope, S. L. Gorbach +5 more
There was a shift in the pattern of urinary metabolites away from the purported carcinogenic estrogen (16 alpha-OHE1) and toward the less active catechol estrogens, which may represent an important mechanism whereby low fat diets decrease the risk of breast cancer.
JAMAWeight Loss in Amateur Wrestlers and Its Effect on Serum Testosterone Levels
107 Citations1985Richard Strauss
Findings suggest that the dietary restriction practiced by some wrestlers may affect serum testosterone levels adversely, and low testosterone levels were significantly correlated with low bodyfat, large loss of body fat, and large weight loss during the wrestling season.
Fertility and SterilityRisk of ovulatory infertility in relation to body weight
104 Citations1988Beverly B. Green, Noel S. Weiss +1 more
The Journal of Clinical Endocrinology & MetabolismHuman Fatty Marrow Aromatizes Androgen to Estrogen
89 Citations1980Rose E. Frisch, Jacob A. Canick +1 more
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The Journal of Clinical Endocrinology & MetabolismEstrogen 2-Hydroxylase Oxidation and Menstrual Function among Elite Oarswomen*
88 Citations1989Rachel Snow, Robert L. Barbieri +1 more
Elevated estradiol 2-hydroxylase oxidation among elite oarswomen is associated with the occurrence of menstrual disturbances during phases of high intensity training and increased relative leanness.
Proceedings of the National Academy of SciencesCarcass components at first estrus of rats on high-fat and low-fat diets: body water, protein, and fat.
87 Citations1977R E Frisch, D.M. Hegsted +1 more
The carcass data support G.C. Kennedy's hypotheses that a metabolic signal, related to fat stores, is a signal for puberty in the rat and are in accord with the hypothesis that a critical body composition of fatness is necessary for estrus in theRat, as in the human female.
PubMedFatness of girls from menarche to age 18 years, with a nomogram.
85 Citations1976Rose E. Frisch
The findings make significant the changes in body composition which take place during the period from menarche to the cessation of growth at about 16-18 years, the period of adolescent sterility, when cycles are often irregular and anovulatory, and pregnancy wastage is high.
DiabetesLower Prevalence of Diabetes in Female Former College Athletes Compared With Nonathletes
84 Citations1986R E Frisch, Grace Wyshak +3 more
It is concluded that long-term athletic training is associated with a lower risk of the development of diabetes.
European Journal of EndocrinologySerum sex hormone-binding globulin during puberty in girls and in different types of adolescent menstrual cycles
82 Citations1984Dan Apter, N.J. Bolton +2 more
Factors other than steroids have to be considered in the regulation of SHBG levels during puberty, because of the weak relationships between serum SHBG and sex steroid concentrations, and the strong relationships between SHBG, weight and body fat percentage.
British Journal of CancerLower prevalence of benign diseases of the breast and benign tumours of the reproductive system among former college athletes compared to non-athletes
71 Citations1986Grace Wyshak, R E Frisch +3 more
Data is reported on the prevalence (lifetime occurrence) of benign breast diseases and benign tumours of the reproductive system among women with former college athletes and non-athletes from 5,398 women.
PubMedExtraglandular oestrogen formation and serum binding of oestradiol: relationship to cancer.
64 Citations1981Siiteri Pk
The possibility exists that nonsteroidal lipids may interfere with E2 binding to SHBG and that dietary fats particularly those containing polyunsaturated fatty acids may promote breast cancer.
American Journal of Clinical NutritionAdipose tissue as a source of hormones
53 Citations1987Pentti K. Siiteri
Evidence is accumulating that dietary macronutrients can alter the metabolism and excretion of endogenous estrogen and androgen, providing a potential mechanism by which diet can modulate the risk of hormone-sensitive cancers.
Human BiologyComponents of Weight at Menarche and the Initiation of the Adolescent Growth Spurt in Girls:Estimated Total Water, Lean Body Weight and Fat
53 Citations2021Frisch, Rose E, Revelle, Roger +1 more
Obstetrical & Gynecological SurveyCALORIC COST OF NORMAL PREGNANCY
53 Citations1973Kendall Emerson, Badri N. Saxena +1 more
Evidence is presented to show that no increased caloric allowance for physical activity during pregnancy is ordinarily required and the mother's future health should be of primary importance in the dietary control of her weight gain during pregnancy.
PubMedEndocrine studies during the refeeding of young women with nutritional amenorrhea and infertility.
48 Citations1976McArthur Jw, O'Loughlin Km +4 more
Serial endocrine studies were performed during the refeeding of a group of nine young women who presented with amenorrhea associated with injudicious dieting and, with continued weight gain, menstruation became regular and the three married patients conceived.
American Journal of RoentgenologyOverall body fat and regional fat distribution in young women: quantification with MR imaging.
39 Citations1991E L Gerard, Rachel Snow +7 more
Experience suggests that MR is an accurate method to quantify overall body fatness, when compared with D2O dilution and bioimpedance analysis, and could also discriminate regional components of subcutaneous and internal body fat at individual landmarks.
PubMedBone fractures among former college athletes compared with nonathletes in the menopausal and postmenopausal years.
39 Citations1987Grace Wyshak, R E Frisch +3 more
When athletic activity was accounted for, the former college athletes were at no greater risk of fractures in the menopausal years than were nonathletes, and among women 60 years and over who were fracture-free up to age 40, the rate for any fracture at age 40 or over was 29% forFormer college athletes compared with 32% for nonathlete, a nonsignificant difference.
The Journal of Clinical Endocrinology & MetabolismMagnetic resonance imaging of overall and regional body fat, estrogen metabolism, and ovulation of athletes compared to controls.
31 Citations1993R E Frisch, Rachel Snow +4 more
Changes in regional fat deposits of both sc and internal fat may be involved in the menstrual dysfunction of the athletes in addition to their decreased overall fatness.
Medicine & Science in Sports & ExerciseLower prevalence of non-reproductive system cancers among female former college athletes
30 Citations1989Rose E. Frisch, Grace Wyshak +3 more
The lower prevalence rate of class I cancers among the former athletes is in accord with previous findings of a significantly lower prevalence rates of breast cancer and cancers of the reproductive system among former college athletes compared to nonathletes.
The Journal of Agricultural Science“Fatness” as a Cause of Sterility
27 Citations1910F. H. A. Marshall, W. R. Peel
The general experience of breeders, supported by statistical evidence in the case of sheep, has shown that a good thriving, but not over-fat, condition during the breeding season is that which is most conducive to a high fertility.
MetabolismMetabolic, endocrine, and reproductive changes of a woman channel swimmer
27 Citations1984Rose E. Frisch, George Hall +8 more
The metabolic changes were associated with reproductive changes, including a shortened luteal phase, absence of ovulation, and increased LH secretion relative to FSH, and the swimmer maintained high levels of body fat; she did not become amenorrheic.
EndocrinologyACCELERATED GROWTH WITH SEXUAL PRECOCITY IN FEMALE MONKEYS RECEIVING TESTOSTERONE PROPIONATE<sup>1</sup>
26 Citations1949G. van Wagenen
MetabolismMagnetic resonance imaging of body fat of athletes compared with controls, and the oxidative metabolism of estradiol
14 Citations1992Rose E. Frisch, Rachel Snow +5 more
The extent of 2-hydroxylation of estradiol (E2), which yields a non-estrogenic metabolite (2-OHE1), increased significantly with decreasing subcutaneous fat (ScF) and total fat (TF) evaluated by magnetic resonance imaging (MRI) for five athletes during low- and high-intensity training, and four controls.
Biodemography and Social BiologyIs lactation nature's contraceptive? Data from Samoa
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This paper explores the applied and theoretical implications of continuing to accept lactation as a universally effective fertility control mechanism, and the implications for family planning programs.