Evidence that β-Amyloid Protein in Alzheimer's Disease Is Not Derived by Normal Processing
SciencePublished 27 April 1990
Sangram S. Sisodia, Edward H. Koo, Konrad Beyreuther, Axel Unterbeck, Donald L. Price
Citations891
SJR quartileQ1
SJR score10.42
SNIP6.62
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TL;DR
An early event in amyloid formation may involve altered APP processing that results in the release and subsequent deposition of intact beta/A4, which is the principal component of senile plaques in Alzheimer's disease.
Abstract
The beta-amyloid protein (beta/A4), derived from a larger amyloid precursor protein (APP), is the principal component of senile plaques in Alzheimer's disease. APP is an integral membrane glycoprotein and is secreted as a carboxyl-terminal truncated molecule. APP cleavage, which is a membrane-associated event, occurred at a site located within the beta/A4 region. This suggests that an intact amyloidogenic beta/A4 fragment is not generated during normal APP catabolism. Therefore, an early event in amyloid formation may involve altered APP processing that results in the release and subsequent deposition of intact beta/A4.
Keywords
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