The Environmental Genome Project: functional analysis of polymorphisms.
Environmental Health PerspectivesPublished 1 July 1998Open access
F. Peter Guengerich
Citations53
SJR quartileQ1
SJR score2.57
SNIP1.98
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TL;DR
Factors to be considered in the design of functional analyses are considered in this commentary and will require analysis of the relevance of the allelic differences in the American population.
Abstract
The ultimate goal of the Environmental Genome Project is the improvement of human health on the basis of information about the variations in certain genes. The first phase of the project will involve the selection of the human genes and characterization of the alleles occurring in the American population. However, intelligent use of this information will require analysis of the relevance of the allelic differences. Epidemiology alone will not solve the problem, and mechanistic studies will be required. Factors to be considered in the design of functional analyses are considered in this commentary.
Keywords
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