Prospective randomized study of N‐acetylcysteine, fenoldopam, and saline for prevention of radiocontrast‐induced nephropathy
Catheterization and Cardiovascular InterventionsPublished 25 October 2002
Suhail Allaqaband, Ramagopal Tumuluri, Ahmed M. Malik, Anjan Gupta, PAUL VOLKERT, Yoseph Shalev
Citations261
SJR quartileQ1
SJR score1.01
SNIP0.91
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TL;DR
In patients with chronic renal insufficiency, NAC or fenoldopam offered no additional benefit over hydration with saline in preventing RCIN, and the efficacy of N‐acetylcysteine, fen oldopam, and saline in preventative preventing radiocontrast‐induced nephropathy was compared.
Abstract
The objective of this study was to compare the efficacy of N-acetylcysteine (NAC), fenoldopam, and saline in preventing radiocontrast-induced nephropathy (RCIN) in high-risk patients undergoing cardiovascular procedures. We prospectively enrolled 123 patients who were scheduled for cardiovascular procedures and had a baseline creatinine > 1.6 mg/dl or creatinine clearance of 0.5 mg/dl after 48 hr. The incidence of RCIN was 17.7% in the NAC group, 15.3% in the saline group, and 15.7% in the fenoldopam group (P = 0.919). Of the 20 patients who developed RCIN, 2 required dialysis. Serum creatinine decreased after 48 hr (vs. baseline) in 38% patients in the NAC group, 18% in the fenoldopam group, and 15% in the saline group. In patients with chronic renal insufficiency, NAC or fenoldopam offered no additional benefit over hydration with saline in preventing RCIN.
Keywords
Medicine
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