Fast Kinetics of the Oxygen Effect in Irradiated Mammalian Cells
International Journal of Radiation Biology and Related Studies in Physics Chemistry and MedicinePublished 1 January 1978Open access
M.E. Watts, Richard L. Maughan, B.D. Michael
Citations37
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Abstract
(1978). Fast Kinetics of the Oxygen Effect in Irradiated Mammalian Cells. International Journal of Radiation Biology and Related Studies in Physics, Chemistry and Medicine: Vol. 33, No. 2, pp. 195-199.
Keywords
Biochemistry, Genetics and Molecular Biology
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Of the several plastics tested for oxygen solubility and diffusion coefficient, only TPX and Mylar seem to offer a hope that they may be suitable as a support for cells in anoxic experiments, and TPX is the only one which allows 10−8 M [O2] to be reached in a reasonable gassing time, assuming a liquid layer only 100 μ thick.
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Oxygen-diffusion curves obtained show that a significant amount of oxygen diffuses to critical sites in the cell during the interpulse time, which can be interpreted as an upper limit to the lifetime of the radiation-induced oxygen-dependent damage.
