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Heroin "Overdose" Death: Contribution of Drug-Associated Environmental Cues

SciencePublished 23 April 1982
Shepard Siegel, Riley E. Hinson, Marvin D. Krank, Jane McCully
Citations303
SJR quartileQ1
SJR score10.42
SNIP6.62

TL;DR

Results of animal experiments performed to evaluate a model of "overdose" deaths among heroin addicts suggest that conditioned drug-anticipatory responses, in addition to pharmacological factors, affect heroin-induced mortality.

Abstract

A model of "overdose" deaths among heroin addicts is proposed which emphasizes recent findings concerning the contribution of drug-associated environmental cues to drug tolerance. Results of animal experiments performed to evaluate this model suggest that conditioned drug-anticipatory responses, in addition to pharmacological factors, affect heroin-induced mortality.

Keywords

MedicineNeuroscience