Guidance on large bowel surveillance for people with two first degree relatives with colorectal cancer or one first degree relative diagnosed with colorectal cancer under 45 years: Table 1
GutPublished 1 October 2002Open access
Malcolm G. Dunlop
Citations61
SJR quartileQ1
SJR score8.87
SNIP4.79
Generate an AI Snapshot to get a quick, structured summary of this paper.
Study Snapshot
ObjectiveStudy objective
MethodsResearch methodology
PopulationPopulation studied
Sample sizeSample sizes
OutcomesStudy outcomes here
ResultsStudy results comes here
LimitationsResearch study limitations comes here
A concise AI-generated summary of the paper will appear here once you click Generate AI Snapshot.
TL;DR
These guidelines are intended to consider the place of large bowel screening for relatives of people who have developed colorectal cancer, as there is evidence for an increased risk of coloreCTal cancer in such people.
Keywords
Medicine
New England Journal of MedicinePrevention of Colorectal Cancer by Colonoscopic Polypectomy
4,594 Citations1993Sidney J. Winawer, Ann G. Zauber +14 more
To address the hypothesis that colonoscopic polypectomy reduces the incidence of colorectal cancer, the results of the National Polyp Study were analyzed with reference to other published results.
GastroenterologyColorectal cancer screening: Clinical guidelines and rationale
1,619 Citations1997Winawer Sj, R. H. Fletcher +17 more
This guideline report presents the panel’s recommendations with respect to screening and surveillance in people at average risk for CRC and those at increased risk because of a family history of CRC or genetic syndromes or a personal history of adenomatous polyps, inflammatory bowel disease, or curative-intent resection of CRC.
GastroenterologyColonoscopic miss rates of adenomas determined by back-to-back colonoscopies
1,546 Citations1997DK Rex, CS Cutler +6 more
Using current colonoscopic technology, there are significant miss rates for adenomas < 1 cm even with meticulous colonoscopy, and the results suggest the need for improvements in colonoscope technology.
CorneaA Follow-up Study
1,238 Citations1990Charles M. Zacks, Richard L. Abbott +1 more
Despite a small degree of continuous cell loss, corneal grafts have a favorable prognosis for long-term clinical stability and the remaining endothelium has a minimal functional reserve, however, resulting in a high risk of graft decompensation after additional endothelial trauma.
New England Journal of MedicineIncidence of Hereditary Nonpolyposis Colorectal Cancer and the Feasibility of Molecular Screening for the Disease
1,167 Citations1998Lauri A. Aaltonen, Reijo Salovaara +18 more
Tumor specimens obtained from 509 consecutive patients with colorectal adenocarcinomas were screened for DNA replication errors and germ-line mutations of the mismatch-repair genes MLH1 and MSH2, finding at least 2 percent had hereditary nonpolyposis coloreCTal cancer.
New England Journal of MedicineA Prospective Study of Family History and the Risk of Colorectal Cancer
786 Citations1994Charles S. Fuchs, Edward L. Giovannucci +4 more
A family history of colorectal cancer is associated with an increased risk of the disease, especially among younger people, and the risk decreased with increasing age.
New England Journal of MedicineCommon Inheritance of Susceptibility to Colonic Adenomatous Polyps and Associated Colorectal Cancers
461 Citations1988Lisa Cannon‐Albright, Mark H. Skolnick +3 more
It is suggested that an inherited susceptibility to colonic adenomatous polyps and colorectal cancer is common and that it is responsible for the majority of colonic neoplasms observed clinically.
GutTowards safer colonoscopy: a report on the complications of 5000 diagnostic or therapeutic colonoscopies.
430 Citations1983Finlay Macrae, Kelvin Guoping Tan +1 more
Recommendations include the avoidance of oversedation, review of previous barium enema films so as to be aware of large polyps which are more likely to bleed, and the recognition of situations where perforation or septicaemia is likely to occur.
The American Journal of GastroenterologyEndoscopic Perforation of The Colon: Lessons From A 10-Year Study
403 Citations2000Monte L. Anderson, Tousif M. Pasha +1 more
Colonoscopy can result in significant morbidity and carries a small risk of death, and endoscopic colon perforations from endoscopy has lower risk.
Annals of Internal MedicineCancer Risk in Relatives of Patients with Common Colorectal Cancer
374 Citations1993David John, Francis T. McDermott +4 more
A casecontrol family study to assess risk for colorectal cancer in relatives and to define possible markers for any increased risk, using a matched casecontrol design.
Journal of Clinical GastroenterologyColonoscopy
371 Citations1992Jerome D. Waye, Blair S. Lewis +1 more
The overall complication rate for therapeutic ambulatory colonoscopy was 5%, with major events requiring hospitalization in 2% of patients, and it is concluded that office Colonoscopy including polypectomy is safe.
JNCI Journal of the National Cancer InstituteFamily History of Cancer and Colon Cancer Risk: the Utah Population Database
206 Citations1994Martha L. Slattery, Richard A. Kerber
The data support the recommendations that individuals who have a first-degree, and possibly a second- or third- Degree, relative with colon cancer should have regular screening for colon cancer.
GastroenterologyScreening for colorectal cancer in a high-risk population
202 Citations1987David M. Eddy, F. Warren Nugent +7 more
The analysis indicates that for screening people over 40 yr old an annual fecal occult blood test may reduce colorectal cancer mortality by about one-third, and the lower cost of the barium enema makes it a more cost-effective strategy.
JAMAPredicting Advanced Proximal Colonic Neoplasia With Screening Sigmoidoscopy
189 Citations1999Theodore R. Levin
Age-specific screening using sigmoidoscopy starting at ages 50 to 55 years and colonoscopy after age 65 years may be justified, and subjects with advanced distal histology and those older than 65 years are at increased risk of advanced proximal neoplasia.
The American Journal of Human GeneticsSystematic Analysis of hMSH2 and hMLH1 in Young Colon Cancer Patients and Controls
162 Citations1998Susan M. Farrington, Juili Lin-Goerke +5 more
Genetic testing of probands with early-onset colorectal cancer, irrespective of family history, is one approach that would allow predictive genetic testing of at-risk relatives, and data indicate that an appreciable proportion of young colon cancer probands carry a germ-line mutation in a DNA mismatch-repair gene.
Scandinavian Journal of GastroenterologyThe Funen Adenoma Follow-up Study: Incidence and Death from Colorectal Carcinoma in an Adenoma Surveillance Program
157 Citations1993Ole Dan Jørgensen, O Kronbörg +1 more
The follow-up strategy has resulted in a mortality from colorectal carcinoma which is reduced when compared with the normal population, in spite of an apparently similar incidence of carcinoma.
BMJScreening and genetic counselling for relatives of patients with colorectal cancer in a family cancer clinic.
143 Citations1990Richard S. Houlston, Victoria Murday +3 more
Family history can be used to identify those at risk of colonic cancer and to target appropriate screening, and faecal occult blood testing was unsatisfactory for those at high risk of colorectal cancer.
International Journal of CancerFamily history of colorectal cancer as a risk factor for benign and malignant tumours of the large bowel. A case‐control study
143 Citations1988Luiguu Bonbllj, H. Martines +3 more
No significant difference in the frequency of first degree relatives with a history of cancer of the large bowel was detected between patients with colorectai cancer and those with adenomatous polyps, and the results closely paralleled those of the previous analysis.
Mayo Clinic ProceedingsManagement of Colonoscopic Perforations
134 Citations1997David R. Farley, Michael P. Bannon +4 more
The increasing use of colonoscopy in practice has resulted in an increased number of iatrogenic colonic perforations, and non-operative management is warranted in carefully selected patients without peritoneal irritation.
CancerIncidence and familial occurrence of colorectal cancer and polyps in a health-care district of Northern Italy
125 Citations1987Maurizio Ponz de Leòn, A. Antonioli +3 more
The earlier rise and peak of age‐specific incidence of polyps as compared to cancer, the similar distribution of benign and malignant neoplasms in the various intestinal tracts, and the similar familial aggregation observed both in the cancer and in the polyp groups further support the “polyp‐cancer sequence” and provide a promising strategy for the prevention of colorectal malignancies.
British journal of surgeryFrequency of familial colorectal cancer
114 Citations1991B. M. Stephenson, P J Finan +4 more
There was a fourfold increase in mortality rate, which was greatest in female relatives of patients with colonic cancer (P < 0.0001), and it is recommended that a careful family history should be obtained from all patients with colorectal cancer.
Diseases of the Colon & RectumColonoscopic screening for neoplasms in asymptomatic first-degree relatives of colon cancer patients
106 Citations1992José G. Guillem, Kenneth A. Forde +4 more
Based on probability curves, males with one FDR afflicted with colon cancer appear to have an increased risk of developing a colonic adenoma beginning at 40 years of age, and support the use of colonoscopy as a routine screening tool in this high-risk group.
GutVariables associated with the risk of colorectal adenomas in asymptomatic patients with a family history of colorectal cancer.
66 Citations1995P Gaglia, Wendy Atkin +5 more
Findings support the view that colonoscopy rather than sigmoidoscopy is the method of choice for screening high risk groups.
Diseases of the Colon & RectumEndoscopic and surgical complications of work-up in screening for colorectal cancer
62 Citations1996J Kewenter, Hans Brevinge
If mortality attributable to colorectal cancer will decrease because of screening, the complication rate is acceptable, and the rate of complications to the work-up is acceptable.
GastroenterologyScreening for colorectal cancer in a high risk population
49 Citations1987David M. Eddy
Although both barium enemas and colonoscopies appear to be effective in reducing mortality, the lower cost of thebarium enema makes it a more cost-effective strategy.
British journal of surgeryScreening for large bowel neoplasms in individuals with a family history of colorectal cancer
48 Citations1992Malcolm G. Dunlop
The American Journal of GastroenterologyEndoscopic perforation of the colon: lessons from a 10-year study
45 Citations2000Maribeth Anderson
The LancetLARGE-BOWEL CANCER IN MARRIED COUPLES IN SWEDEN
35 Citations1980Ole Møller Jensen, P. Sigtryggsson +4 more
The cause of death in 1951-1977 and cancer morbidity in 1959-73 were determined and the risk of colorectal cancer and other possibly aetiologically related diseases was no higher in the spouses than in a matched population.
PubMed[Complications of diagnostic and interventional colonoscopy].
30 Citations1996Rudolf Puchner, S Allinger +3 more
The results show that the risks are greatest with relatively inexperienced physicians but are not entirely avoidable even with the most experienced endoscopists, and life-threatening complications related to the performance of flexible fiberoptic colonoscopies are rare.
BMJScreening for people with a family history of colorectal cancer: Table
27 Citations1997Malcolm G. Dunlop, H. Campbell
PubMedA cost analysis of screening methodology for family members of colorectal cancer patients.
21 Citations1989Paul Rozen, Ron E
Calculations of costs indicate that screening asymptomatic adults by colonoscopy is markedly (4-fold) more cost-effective if they have two or more first-degree colon cancer relatives.
British journal of surgeryScreening for large bowel neoplasms individuals with a family history of colorectal cancer
5 Citations1992Lesley Hunt, N C Armitage +1 more
