Synthesis of a New Chiral<i>N,N,N</i>-Tridentate Pyridinebisimidazoline Ligand Library and Its Application in Ru-Catalyzed Asymmetric Epoxidation
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TL;DR
A small ligand library of chiral tridentate N,N,N-pyridinebisimidazolines have been synthesized for the first time and good yields and enantioselectivities have been obtained for the epoxidation of aromatic olefins.
Abstract
A small ligand library of chiral tridentate N,N,N-pyridinebisimidazolines have been synthesized for the first time. This new class of ligands can be easily tuned and synthesized on multi g-scale. The usefulness of the ligands is shown in the ruthenium-catalyzed asymmetric epoxidation with hydrogen peroxide as oxidant. Excellent yields (>99%) and good enantioselectivities (up to 71% ee) have been obtained for the epoxidation of aromatic olefins. [reaction: see text]