Neurogenesis in adult primate neocortex: an evaluation of the evidence
Nature reviews. NeurosciencePublished 1 January 2002
Pasko Rakić
Citations494
SJR quartileQ1
SJR score9.33
SNIP5.31
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TL;DR
Here, the available evidence is reviewed, and the scientific basis of the claim that continuous genesis and turnover of neurons in the adult primate association neocortex is questioned is questioned.
Abstract
Reports of continuous genesis and turnover of neurons in the adult primate association neocortex--the site of the highest cognitive functions--have generated great excitement. Here, I review the available evidence, and question the scientific basis of this claim.
Keywords
NeuroscienceBiochemistry, Genetics and Molecular Biology
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ScienceCell Proliferation Without Neurogenesis in Adult Primate Neocortex
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The Journal of Comparative NeurologyTime of origin of corresponding cell classes in the cerebral cortex of normal and reeler mutant mice: An autoradiographic analysis
415 Citations1973V.S. Caviness, Richard L. Sidman
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Results suggest that proliferating cell nuclear antigen mRNA is expressed not only in proliferating cells but also in nonproliferating cells such as neurons.
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75 Citations1990Kieran W. McDermott, P. L. Lantos
Proliferating cells were numerous in neonates, though not adjacent to the ependyma where counts for the LI were made, and were mainly located dorsally and ventrally at the junctions of the corpus callosum and caudate nucleus.
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Journal of Theoretical BiologyEvidence for a Postnatal Doubling of Neuron Number in the Developing Human Cerebral Cortex Between 15 Months and 6 Years
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Data indicate that γ‐enolase gene expression is associated with the differentiation of the oligodendrocytes and that it is repressed in adult fully mature cells.
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PubMedAutoradiographic studies of glial proliferation in different areas of the brain of the 14-day-old rat.
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Journal of Theoretical BiologyFacts and Fictions Regarding Post-natal Neurogenesis in the Developing Human Cerebral Cortex
15 Citations1999Hubert Korr, Christoph Schmitz
The present paper makes clear by discussing four main assumptions done by Shankle et al., i.e. shrinkage of the tissue, morphometric features of the neurons under study, conversion of cell densities per area to number per unit volume and estimation of coefficients of variation, that their final conclusion about an increase in neuron number is unsound.
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Evidence that individual neurons respond to specific temporal patterns suggests a model for how rhythms may be encoded, particularly at the medium time-scales over which rhythmic patterns are perceived.