Strain-dependent decrease in glutamate binding to the acid receptor during aging
Neuroscience LettersPublished 1 October 1989
Christine Peterson, Carl W. Cotman
Citations75
SJR quartileQ2
SJR score0.77
SNIP0.67
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TL;DR
The data suggest that the age-related decline in glutamate binding to the NMDA receptor may predict a strain-specific reduction in NMDA-mediated processes (e.g. long-term potentiation, postsynaptic calcium fluxes).
Abstract
Glutamate binding to the N-methyl-D-aspartic acid (NMDA) receptor decreases in two strains of aged mice. In BALB/c mice the Bmax values decline 16% by 10 months and 45% by 30 months of age when compared to 3 months. The Kd increased more by 10 months (+29%) than by 30 months (+14%). In the C57Bl strain the Bmax was unaltered by 10 months but decreased 17% by 30 months. The Kd values, however, increased 121% by 10 months and 283% by 30 months of age. These data suggest that the age-related decline in glutamate binding to the NMDA receptor may predict a strain-specific reduction in NMDA-mediated processes (e.g. long-term potentiation, postsynaptic calcium fluxes).
Keywords
MedicineNeuroscienceBiochemistry, Genetics and Molecular Biology
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