Open-field behavior in mice: Analysis of maternal effects by means of ovarian transplantation
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TL;DR
Ovaries from donors of each of two inbred strains were transplanted into F1 hybrid recipients and by appropriate matings it was possible to obtain inbred offspring carried by either hybrid or inbred mothers.
Abstract
Ovaries from donors of each of two inbred strains (BALB/cJ and C57BL/6J) were transplanted into F1 hybrid recipients. By appropriate matings it was thus possible to obtain inbred offspring carried by either hybrid or inbred mothers. Differences in the maternal environment were found to account for a relatively small proportion of the total variance in open-field behavior, but accounted for a relatively large proportion of the variance in body weight.