Omega-3 fatty acids: molecular approaches to optimal biological outcomes
Current Opinion in LipidologyPublished 12 January 2005
Toru Seo, William S. Blaner, Richard J. Deckelbaum
Citations111
SJR quartileQ1
SJR score1.34
SNIP1.11
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TL;DR
This review discusses recent advances in delineating basic mechanisms whereby ω-3 fatty acids modulate cellular pathways to exert beneficial effects on promoting health and decreasing risks of certain diseases.
Abstract
Omega-3 fatty acids are major regulators of multiple molecular pathways, altering many areas of cellular and organ function, metabolism and gene expression. Generally, these regulatory events lead to "positive" endpoints relating to health and disease.
Keywords
Biochemistry, Genetics and Molecular BiologyNursing
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89 Citations2004Christel J. A. W. van Gool, Maurice P. Zeegers +1 more
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89 Citations2003Éric Dewailly, Carole Blanchet +3 more
Results indicate that increased consumption of fish as a source of n−3 fatty acids is beneficially associated with levels of HDL cholesterol and triacylglycerols.
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86 Citations2001Toru Seo, Peter Oelkers +4 more
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78 Citations2002Joan-Carles Vallvé, K. Uliaque +5 more
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77 Citations2002Kemin Qi, Marni Hall +1 more
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73 Citations2002Yousuke Takemura, Yutaka Sakurai +6 more
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It is demonstrated that dietary ω-3 fatty acids prevent colon cancer, at least in part, through inhibition of colonic PKCβII signaling and restoration of TGF-β responsiveness.
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43 Citations2004Clemens von Schacky
Eicosapentaenoic and docosahexaenoic acids, but not α-linolenic acid, prevent sudden death and other cardiovascular catastrophies, and have been recently incorporated into the pertinent guidelines of European and American cardiologic societies.
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Posttransplant intravenous alimentation with fish oil-derived lipid emulsions prolongs heart transplant survival in excess to omega-6 lipids andounds changes in fatty acid profiles and lipid mediator generation.
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41 Citations2003Hee‐Yong Kim, Mohammed Akbar +1 more
The data suggest that depletion of DHA from neuronal tissues may have a compounding effect on Raf-1 translocation in growth factor signaling and the fact that DPA cannot fully support the protective role played by DHA may provide a basis for the adverse effect of n−3 FA deficiency on neuronal development and function.
AtherosclerosisSerum non-esterified very long-chain PUFA are associated with markers of endothelial dysfunction
39 Citations2002Paula Yli-Jama, Ingebjørg Seljeflot +4 more
Taking together, negative associations were found between sVCAM-1 and the serum levels of non-esterified DHA, EPA and AA, and the inverse relation between the levels of sVCams1 and very long-chain n-3 fatty acids might indicate an anti-inflammatory effect of the latter.
CarcinogenesisDietary fish oil blocks carcinogen-induced down-regulation of colonic protein kinase C isozymes
37 Citations1997Y H Jiang
It is demonstrated that dietary fish oil blocks the carcinogen-induced decrease in the steady-state levels of colonic mucosal PKC delta and lambda-zeta, which may in part explain why this fat source protects against colon cancer development.
The Cancer JournalEicosapentaenoic Acid Induces Fas-Mediated Apoptosis Through a p53-Dependent Pathway in Hepatoma Cells
35 Citations2004Tianyi Chi, George G. Chen +1 more
It appears that the effects of EPA on hepatoma cells are determined by the status of p53 and that wild-type p53 is a prerequisite for the anticancer effect of EPA.
American Journal of Physiology-Regulatory, Integrative and Comparative PhysiologyDocosahexaenoic acid affects insulin deficiency- and insulin resistance-induced alterations in cardiac mitochondria
32 Citations2004Stéphanie Ovide‐Bordeaux, Alain Grynberg
The impairment of cardiac mitochondrial function was more pronounced in the insulin-deficient state than in insulin resistance, and the modification of fatty acid composition of cardiac and mitochondrial membranes by DHA partially prevented the mitochondrial alterations induced in the two models.
PharmacopsychiatryEffects of Phosphatidylserine Administration on Age-Related Structural Changes in the Rat Hippocampus and Septal Complex
18 Citations1989M.G. Nunzi, F. Javier Milán +3 more
Dendritic spine density of CA1 pyramidal neurons in the hippocampus and morphometric characteristics of the cholinergic neuronal population of the septal complex, were evaluated in young, aged, and age-matched rats which had received long-term phosphatidylserine administration.
CarcinogenesisFish oil constituent docosahexa-enoic acid selectively inhibits growth of human papillomavirus immortalized keratinocytes
17 Citations1999Daxin Chen
Effects of omega-3-fatty acids on human pre-cancerous cells were examined and docosahexaenoic acid inhibited growth in the presence of estradiol, a growth stimulator for these cells.
Biochemical Society TransactionsModulation of colonocyte proliferation and apoptosis by dietary fish oil in experimental colorectal carcinogenesis
10 Citations1998Peter Latham, Elizabeth K. Lund +1 more
The objectives of this study were to determine the effects of short-term fish oil dietary supplementation on colonocyte proliferation and spontaneous apoptosis in the distal colon of normal healthy animals and provide insight into the influence of fish oil on crypt cell kinetics immediately following carcinogenic insult with 1,2 dimethylhydrazine (DMH).
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