Males with an XYY sex chromosome complement.
Journal of Medical GeneticsPublished 1 December 1968Open access
W.M. Court Brown
Citations141
SJR quartileQ1
SJR score1.62
SNIP1.40
Generate an AI Snapshot to get a quick, structured summary of this paper.
Study Snapshot
ObjectiveStudy objective
MethodsResearch methodology
PopulationPopulation studied
Sample sizeSample sizes
OutcomesStudy outcomes here
ResultsStudy results comes here
LimitationsResearch study limitations comes here
A concise AI-generated summary of the paper will appear here once you click Generate AI Snapshot.
TL;DR
There exist serious imperfections in knowledge of the range of phenotypes that may be linked with this abnormal chromosome complement, and it is by no means certain that impaired testicular descent was merely a chance association with the XYY complement in some of the cases described in this first phase.
Keywords
Biochemistry, Genetics and Molecular Biology
Archives of Disease in ChildhoodStandards from birth to maturity for height, weight, height velocity, and weight velocity: British children, 1965. II.
2,565 Citations1966J. M. Tanner, R. H. Whitehouse +1 more
The solution to the alternatives of plotting against chronological or developmental age at adolescence is adopted and centiles plotted against chronological age over the whole age span are given.
Archives of Disease in ChildhoodStandards from birth to maturity for height, weight, height velocity, and weight velocity: British children, 1965. I.
1,346 Citations1966J.M. Tanner, R. H. Whitehouse +1 more
The accurate assessment of the physical growth and development of children has recently come to interest paediatricians and public health officers much more than hitherto.
NatureAggressive Behaviour, Mental Sub-normality and the XYY Male
430 Citations1965Patricia A. Jacobs, MURIEL BRUNTON +3 more
The purpose of this communication is to report the findings in a survey of mentally sub-normal male patients with dangerous, violent or criminal propensities in an institution where they are treated under conditions of special security.
Archives of Disease in ChildhoodAbnormalities of the Sex Chromosome Complement in Man
151 Citations1964W. M. COURT-BROWN, D.G. Harnden +3 more
BMJBehaviour disorders and pattern of crime among XYY males identified at a maximum security hospital.
140 Citations1967W. H. Price, P. B. Whatmore
It is probably too early to conclude that there is adrenal hyperfunction in affluent westerners; the results might merely indicate alteration in thyroid function and faster steroid turnover.
NatureSex Chromosome Abnormalities in Two State Hospitals for Patients requiring Special Security
122 Citations1966M. D. Casey, Leslie Segall +2 more
A survey on a group of socially disturbed males of relatively normal intelligence failed to show an increase in sex chromatin abnormality, and it was suggested that an abnormal sex chromosome complement might predispose to delinquency.
Annals of Human GeneticsChromosome studies on men in a Maximum Security Hospital
96 Citations1968Patricia A. Jacobs, W. H. Price +3 more
Chromosome studies were done on 315 out of 342 men at the State Hospital, Carstairs, Scotland, a hospital for the treatment of patients with dangerous, violent, or criminal propensities in contitions of special securtiy.
NatureSex Chromosome Abnormalities
94 Citations1967Richard M. Goodman, William S. Smith +1 more
Evidence is beginning to suggest that genetic factors influence criminal behaviour, and Jacobs et al.5 have called attention to the criminal behaviour of males with the XYY sex chromosome complement.
PEDIATRICSTHE FREQUENCY OF THE POSITIVE SEX-CHROMATIN PATTERN IN MALES WITH MENTAL DEFICIENCY
94 Citations1960H. David Mosier, Lawrence W. Scott +1 more
PEDIATRICSBENIGN CONGENITAL HYPOTONIA WITH CHROMOSOMAL ANOMALY
82 Citations1961Henry G. Dunn, Denys K. Ford +2 more
The clinical syndrome of benign congenital hypotonia is made to, which corresponds to Oppenheim's original concept of a sporadic benign condition and represents the cases of amyotonia not due to infantile progressive muscular atrophy on symptomatic of any other disease entity.
NaturePsychopathy, Mental Deficiency, Aggressiveness and the XYY Syndrome
66 Citations1967John P. Welch, D. S. Borgaonkar +1 more
Preliminary findings are reported from a survey in a comparable population in the United States of mentally sub-normal male patients with “dangerous, violent or criminal propensities” found that seven of 197 inmates had an XYY sex chromosome constitution.
The Journal of Clinical Endocrinology & MetabolismXYY Karyotype in a Case of Familial Hypogonadism
62 Citations1966Marios C. Balodimos, Hermann Lisco +3 more
Two brothers are described who showed the clinical picture of hypogonadism with seminiferous tubule dysgenesis, gynecomastia and elevated urinary gonadotrophins resembling Klinefelter's syndrome, with an XYY karyotype found in one of the brothers, while the other presented the normal male chromosome pattern.
BMJFurther information on the identity of 47,XYY males.
47 Citations1968W.M. Court Brown, W. H. Price +1 more
The germ of an idea for explaining how malformations are produced by chromosomal aberrations is explained, because this branch of pathology is shrouded in complete darkness.
New England Journal of MedicineXYY Genotype
47 Citations1963Avery A. Sandberg, Takaaki Ishihara +2 more
NatureChromosomes of Male Patients in a Security Prison
40 Citations1968D. J. Bartlett, W. P. HURLEY +2 more
A chromosomal survey of 204 male inmates from a security prison for the psychiatric treatment of offenders revealed five individuals of abnormal karyotype.
The Journal of Pediatrics21 trisomy with an XYY sex chromosome complement
36 Citations1966Irene A. Uchida, M. Ray +1 more
The child exhibited the typical clinical stigmas and dermatoglyphics of the 21 trisomy syndrome with no unusual features to suggest the presence of an extra Y chromosome.
The Journal of Clinical Endocrinology & MetabolismMale Pseudohermaphrodism with XYY Sex Chromosomes
34 Citations1967Robert C. Franks, Kenneth W. Bunting +1 more
A second case of phenotypic sex reversal associated with XYY sex chromosomes is described and possible mechanisms of the clinical variations seen among patients with an XYY genotype are discussed.
GeneticaAn XYY chromosome pattern in a boy with Marfan's syndrome
34 Citations1964T. W. J. Hustinx, A. H. F. van Olphen
In three siblings (two girls and a boy) the authors diagnosed the Marfan syndrome; the boy appeared to have 47 chromosomes; his chromosome pattern was interpreted as XYY; there are no indications for a specific clinical picture going with the XYY chromosome pattern.
The British Journal of PsychiatryPsychological Characteristics Associated with XYY Sex-Chromosome Complement in a State Mental Hospital
31 Citations1967Keith Hope, A. E. Philip +1 more
BMJXYY constitution in prepubertal child.
29 Citations1968J. Cowie, Jeffrey B. Kahn
It is suggested that when patients with dermatomyositis fail to improve when given large doses of steroids a careful search should be made for an underlying neoplasm, and that this should include studies for M-band and Bence Jones protein.
Cytogenetic and Genome ResearchThe incidence of sex chromosomal abnormalities in mentally subnormal males
23 Citations1968H.G. Close, A.S.R. Goonetilleke +2 more
Advances in experimental medicine and biologyChromosome Studies on Testicular Cells of Subfertile Men
16 Citations1970Ann C. Chandley
Obstetrical & Gynecological SurveyCHROMOSOME STUDIES ON TESTICULAR CELLS FROM 50 SUBFERTILE MEN
11 Citations1967Maureen E. McIlree, W. H. Price +4 more