Effect of Very Small Concentrations of Insulin on Forearm Metabolism. Persistence of Its Action on Potassium and Free Fatty Acids without Its Effect on Glucose*
Journal of Clinical InvestigationPublished 1 May 1964Open access
Kenneth L. Zierler, D. Rabinowitz
Citations335
SJR quartileQ1
SJR score4.72
SNIP2.17
Generate an AI Snapshot to get a quick, structured summary of this paper.
Study Snapshot
ObjectiveStudy objective
MethodsResearch methodology
PopulationPopulation studied
Sample sizeSample sizes
OutcomesStudy outcomes here
ResultsStudy results comes here
LimitationsResearch study limitations comes here
A concise AI-generated summary of the paper will appear here once you click Generate AI Snapshot.
Keywords
MedicineBiochemistry, Genetics and Molecular Biology
Journal of Clinical InvestigationIMMUNOASSAY OF ENDOGENOUS PLASMA INSULIN IN MAN
3,035 Citations1960Rosalyn S. Yalow, Solomon A. Berson
Journal of Clinical InvestigationFOREARM METABOLISM IN OBESITY AND ITS RESPONSE TO INTRA-ARTERIAL INSULIN. CHARACTERIZATION OF INSULIN RESISTANCE AND EVIDENCE FOR ADAPTIVE HYPERINSULINISM*
522 Citations1962D. Rabinowitz, Kenneth L. Zierler
Metabolism of obese subjects has been examined by measuring metabolic events in the forearm, which is predominantly skeletal muscle and adipose tissue, in the search for answers to the following questions.
Obesity ResearchIMMUNOASSAY OF ENDOGENOUS PLASMA INSULIN IN MAN
460 Citations1996Rosalyn S. Yalow, Solomon A. Berson
The insulin concentration in plasma has been estimated from the degree of hypoglycemia produced in hypophysectomized, adrenalectomization, alloxan-diabetic rats, and from the increased oxidation of glucose-1-C14 by the rat epididymal fat pad.
Journal of Clinical InvestigationTHE QUANTITATIVELY MINOR ROLE OF CARBOHYDRATE IN OXIDATIVE METABOLISM BY SKELETAL MUSCLE IN INTACT MAN IN THE BASAL STATE. MEASUREMENTS OF OXYGEN AND GLUCOSE UPTAKE AND CARBON DIOXIDE AND LACTATE PRODUCTION IN THE FOREARM 12
390 Citations1956Reubin Andres, Gordon Cader +1 more
Studies of excised muscle and its extracts have shown a great deal about the apparatus with which muscle is equipped to perform its functions in dissimilating metabolites but they fail to reveal the quantitative importance of particular pathways of dissimilation in the total scheme.
BiochemistryStudies on the Metabolism of Adipose Tissue. XII. The Effects of Insulin and Epinephrine on Free Fatty Acid and Glycerol Production in the Presence and Absence of Glucose<sup>*</sup>
377 Citations1963Robert L. Jungas, Eric G. Ball
NatureA Metabolic Regulating Device based on the Actions of Human Growth Hormone and of Insulin, Singly and Together, on the Human Forearm
188 Citations1963D. Rabinowitz, Kenneth L. Zierler
Placed in juxtaposition to observations from this laboratory on the effects of close intra-arterial injection of insulin and of human growth hormone, singly and together, on muscle and adipose tissue metabolism in situ in the forearm of man, it provides a clearer picture of the day-to-day role ofhuman growth hormone and of insulin, and thus of their place in the economy of the normal adult.
Journal of Clinical InvestigationHETEROGENEITY OF FOREARM METABOLISM WITH SPECIAL REFERENCE TO FREE FATTY ACIDS*
184 Citations1962Marc Baltzan, Reubin Andres +2 more
Data showed that resting skeletal muscle of the forearm, with the subject in the basal state, consumed oxygen vigorously and that only 7 + 71 per cent of its 02 uptake could be accounted for by oxidation of glucose abstracted from arterial blood.
Journal of Clinical InvestigationEFFECT OF GLUCOSE AND INSULIN ON THE ESTERIFICATION OF FATTY ACIDS BY ISOLATED ADIPOSE TISSUE *
172 Citations1960M. S. Raben, C. H. Hollenberg
Journal of Clinical InvestigationROLE OF FREE FATTY ACIDS IN FOREARM METABOLISM IN MAN, QUANTITATED BY USE OF INSULIN*
165 Citations1962D. Rabinowitz, Kenneth L. Zierler
While FFA is being extracted from plasma by forearm muscle, adipose tissue, intimately surrounding muscle, adds fatty acid to venous plasma, and the net A DV FFA difference is determined by the relative rates of these two processes.
American Journal of Clinical NutritionFactors Concerned with the Regulation of Fatty Acid Metabolism by Adipose Tissue
158 Citations1960George F. Cahill, Bernard Lebœuf +1 more
Journal of Clinical InvestigationEFFECT OF INSULIN ON CARBOHYDRATE METABOLISM AND ON POTASSIUM IN THE FOREARM OF MAN*
154 Citations1962Reubin Andres, Marc Baltzan +2 more
The effects on forearm muscle metabolism of insulin administered in this fashion are described, finding no detectable systemic counter-regulatory processes set in motion by the agent to complicate the primary response of the forearm to the agent itself.
American Journal of Physiology-Legacy ContentEffect of insulin on membrane potential and potassium content of rat muscle
143 Citations1959Kenneth L. Zierler
It is suggested that the hyperpolarization produced by insulin is the cause of the potassium shift and the increase in intracellular K is probably too small and too late to account for the hyperPolarization on the basis of conventional theory.
Experimental Biology and MedicineEffect of Insulin upon Resting Electrical Potential of Adipose Tissue.
121 Citations1962Paul M. Beigelman, Philip B. Hollander
Significant increase of cell membrane resting electrical potential (REP) of adipose tissue obtained from young rats occurred in response to 1-1,000 micro-units/ ml of insulin.
American Journal of Physiology-Legacy ContentEffect of insulin on potassium efflux from rat muscle in the presence and absence of glucose
119 Citations1960Kenneth L. Zierler
Potassium efflux from rat extensor digitorum longus muscle was measured by counting the decrease in K42 in muscle bathed in K41-free solution and the rate constant for K efflux was 0.27 hr.–1 at 37°C.
American Journal of Physiology-Legacy ContentHyperpolarization of muscle by insulin in a glucose-free environment
73 Citations1959Kenneth L. Zierler
It is concluded that insulin hyperpolarizes muscle membrane, as a result of which potassium moves into muscle, and that the eventual effect of insulin on potassium movement can be independent of any effect insulin may also have on glucose uptake.