An improved method for the stereoselective synthesis of β-lactams from carboxylic acids and imines

Abstract

Carboxylic acids activated with Mukaiyama's reagent (2-chloro-N-methylpyridinium iodide) reacted with imines to produce β-lactams in good yields and with high stereoselectivity. The utilization of three equivalents of tripropylamine as the base was necessary to obtain high chemical yield and good stereoselectivity.