Immunohistochemical demonstration of neuron-specific enolase and microtubule-associated protein 2 in reactive astrocytes after injury in the adult forebrain
NeurosciencePublished 1 May 1994
R.C.S. Lin, Diane F. Matesic
Citations45
SJR quartileQ2
SJR score1.01
SNIP0.76
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TL;DR
Using double immunofluorescent labeling methods, astrocytes in both the ischemically damaged and the retrogradely/anterogradely degenerating forebrain nuclei express not only glial cell markers glial fibrillary acidic protein and vimentin, but also the neuronal markers neuron-specific enolase and microtubule-associated protein 2.
Abstract
Transformation of normal resting astrocytes to reactive astrocytes in the adult brain after injury has been well documented. Using double immunofluorescent labeling methods, we report that astrocytes in both the ischemically damaged and the retrogradely/anterogradely degenerating forebrain nuclei express not only the glial cell markers glial fibrillary acidic protein and vimentin, but also the neuronal markers neuron-specific enolase and microtubule-associated protein 2. Since these neuronal markers are expressed in glial precursor cells, these results suggest that one of the characteristic responses of astrocytes in the adult brain after injury may be re-expression of fetal trait(s) of early differentiating glial cells/neurons.
Keywords
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