Ascending Endorphin Inhibition of Distress Vocalization
SciencePublished 6 March 1981
Barbara H. Herman, Jaak Panksepp
Citations193
SJR quartileQ1
SJR score10.42
SNIP6.62
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TL;DR
Evidence is provided for ascending endorphin-mediated inhibition of excitatory forebrain sites for distress vocalizations in adult guinea pigs.
Abstract
Distress vocalizations were produced in adult guinea pigs by electrical stimulation of the dorsomedial thalamus or the septum-preoptic area. Both of these forebrain-derived vocalizations were increased by systemic administration of naloxone and were inhibited by analgesic periventricular gray stimulation. Naloxone blocked the inhibitory effects of the analgesic stimulation on thalamic vocalizations. Stimulation of nonanalgesic mesencephalic sites in close proximity to the periventricular gray increased the anterior-elicited vocalizations. These data provide evidence for ascending endorphin-mediated inhibition of excitatory forebrain sites for distress vocalizations.
Keywords
PsychologyNeuroscienceHealth Professions
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