5-Hydroxytryptamine metabolism in affective illness: the effect of tryptophan administration
Psychological MedicinePublished 1 August 1973
G Ashcroft, T. B. B. Crawford, Richard Cundall, David Davidson, Janet Dobson, R. C. Dow
Citations51
SJR quartileQ1
SJR score2.42
SNIP1.85
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TL;DR
Findings suggest a reduced neuronal activity in the 5-hydroxytryptaminergic system in some depressed patients rather than an absolute deficiency of tryptophan-5-hydroxylase.
Abstract
SYNOPSIS L-tryptophan 50 mg/kg was administered orally to patients suffering from either unipolar or bipolar affective illness, and the concentration of 5-hydroxyindol-acetic acid estimated in their cerebrospinal fluid eight hours later. There was no significant difference between the patient groups or between these and patients with neurological disease. These findings suggest a reduced neuronal activity in the 5-hydroxytryptaminergic system in some depressed patients rather than an absolute deficiency of tryptophan-5-hydroxylase. The synthesis of 5-HIAA in response to tryptophan varied with age.
Keywords
PsychologyMedicineNeuroscience
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