An improved method for studying the psychogalvanic reaction in mice and its inhibition by psycholeptic drugs. Comparison with the effects of other pharmacological agents
PsychopharmacologyPublished 1 January 1974
R Marcy, M. A. Quermonne
Citations54
SJR quartileQ1
SJR score1.16
SNIP0.97
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TL;DR
Providing one discounts drugs inhibiting the PGR by peripheral anticholinergic or adrenolytic activity and those which inhibit the P GR at dosages which are similar to the motor depressant dosages, the method is valid for screening and studying psycholeptic drugs.
Abstract
An apparatus and a quantitative method for studying the spontaneous palmar conductivity (SPC) and the psychogalvanic reaction (PGR) in mice are described. Several psycholeptics (neuroleptics, tranquillizers, hypnotics) were tested. In order to assess the specificity of the method, several other pharmacological agents (muscle relaxants, neuromusclar blocking agents, anticholinergics, α-adrenolytics) were tested. A comparison of the active doses of these various products on SPC, PGR, prehension and traction reflexes shows that psycholeptics and more particularly neuroleptics and tranquillizers inhibit PGR at low dosages. These are smaller than the motor test inhibitory dosages and far lower than LD50. Providing one discounts drugs inhibiting the PGR by peripheral anticholinergic or adrenolytic activity and those which inhibit the PGR at dosages which are similar to the motor depressant dosages, the method is valid for screening and studying psycholeptic drugs.
Keywords
Medicine
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