Chronic intracerebroventricular infusion of insulin causes selective increase of slow wave sleep in rats
Brain ResearchPublished 1 July 1984
Jaber Danguir, Stylianos Nicolaids
Citations76
SJR quartileQ2
SJR score0.85
SNIP0.72
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TL;DR
Sleep patterns were continuously recorded in rats receiving chronic intracerebroventricular infusions of insulin and administration of insulin resulted in a selective increase of the daily duration of slow wave sleep, whereas the duration of paradoxical sleep remained unchanged.
Abstract
Sleep patterns were continuously recorded in rats receiving chronic intracerebroventricular (i.c.v.) infusions of insulin. The i.c.v. administration of insulin resulted in a selective increase (25%) of the daily duration of slow wave sleep (SWS), whereas the duration of paradoxical sleep (PS) remained unchanged. The neutralization of peripheral and/or central insulin by means of continuous intravenous or i.c.v. infusions of anti-insulin serum brought about a selective decrease of SWS, whereas PS remained unchanged. The present findings are discussed with regard to the present knowledge of the origin and the role of brain insulin.
Keywords
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