Right Hemisphere Activation during Indirect Semantic Priming: Evidence from Event-Related Potentials
Brain and LanguagePublished 1 October 1998
Markus Kiefer, Matthias Weisbrod, Isabel Kern, Sabine Maier, Manfred Spitzer
Citations142
SJR quartileQ1
SJR score0.93
SNIP1.03
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TL;DR
The hypothesis that the right hemisphere semantic system is involved in processing of remote semantic information is supported by the results of a semantic priming paradigm study on healthy subjects.
Abstract
Healthy subjects performed a lexical decision task in a semantic priming paradigm while event-related potentials (ERPs) were recorded from 64 channels. Semantic distance between prime and target was varied by including directly, indirectly, and nonrelated word pairs. At centro-parietal electrodes an N400 to nonrelated pairs was elicited bilaterally which was sensitive only to direct, but not to indirect semantic priming. These N400 priming effects were mirrored by the RT data. At inferior fronto-temporal sites directly related words showed ERP priming effects over both hemispheres. However, indirectly related words only elicited ERP priming effects over the right hemisphere. These results support the hypothesis that the right hemisphere semantic system is involved in processing of remote semantic information.
Keywords
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NeuropsychologiaThe assessment and analysis of handedness: The Edinburgh inventory
36,704 Citations1971R. C. Oldfield
An inventory of 20 items with a set of instructions and response- and computational-conventions is proposed and the results obtained from a young adult population numbering some 1100 individuals are reported.
Psychological ReviewA spreading-activation theory of semantic processing.
8,093 Citations1975Allan M. Collins, Elizabeth F. Loftus
The present paper shows how the extended theory can account for results of several production experiments by Loftus, Juola and Atkinson's multiple-category experiment, Conrad's sentence-verification experiments, and several categorization experiments on the effect of semantic relatedness and typicality by Holyoak and Glass, Rips, Shoben, and Smith, and Rosch.
The Psychology of learning and motivation/The psychology of learning and motivationThe Psychology of Learning and Motivation: Advances in Research and Theory
6,039 Citations2010
ScienceReading Senseless Sentences: Brain Potentials Reflect Semantic Incongruity
4,926 Citations1980Marta Kutas, Steven A. Hillyard
In a sentence reading task, words that occurred out of context were associated with specific types of event-related brain potentials that elicited a late negative wave (N400).
Electroencephalography and Clinical NeurophysiologySpherical splines for scalp potential and current density mapping
2,777 Citations1989Fabien Perrin, J. Pernier +2 more
Description of mapping methods using spherical splines, both to interpolate scalp potentials (SPs) and to approximate scalp current densities (SCDs) with greater accuracy in areas with few electrodes.
Journal of Experimental Psychology GeneralSemantic priming and retrieval from lexical memory: Roles of inhibitionless spreading activation and limited-capacity attention.
2,733 Citations1977James H. Neely
NaturePositron emission tomographic studies of the cortical anatomy of single-word processing
2,624 Citations1988Steven E. Petersen, Peter T. Fox +3 more
The use of positron emission tomography to measure regional changes in average blood flow during processing of individual auditory and visual words provides support for multiple, parallel routes between localized sensory-specific, phonological, articulatory and semantic-coding areas.
Attention And Cognitive Control 1
2,322 Citations2024Michael I. Posner, C. R. Snyder
NatureBrain potentials during reading reflect word expectancy and semantic association
2,232 Citations1984Marta Kutas, Steven A. Hillyard
The amplitude of the N400 component of the e.r.p.ps was found to be an inverse function of the subject's expectancy for the terminal word as measured by its ‘Cloze probability’, which suggests N400 may reflect processes of semantic priming or activation.
Language<b>Handbook of psycholinguistics.</b> Ed. by Morton Ann Gernsbacher. New York: Academic Press, 1994, Pp. 1174.
1,938 Citations1996Helen Smith Cairns
Medical Entomology and ZoologySemantic priming effects in visual word recognition : A selective review of current findings and theories
1,847 Citations1991J. G. NEELY
Journal of Memory and LanguageEvent-related brain potentials elicited by syntactic anomaly
1,822 Citations1992Lee Osterhout, Phillip J. Holcomb
Cerebral CortexPractice-related Changes in Human Brain Functional Anatomy during Nonmotor Learning
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Support for the general hypothesis that the human brain localizes mental operations of the kind posited by cognitive theories is integrated in the performance of cognitive tasks such as reading comes from studies in mental imagery, timing, and memory.
Journal of Cognitive NeurosciencePositron Emission Tomographic Studies of the Processing of Singe Words
1,307 Citations1989Steven E. Petersen, Peter T. Fox +3 more
PET images of blood flow change that were averaged across individuals were used to identify brain areas related to lexical (single-word) processing, and a small number of discrete areas were activated during several task conditions.
Journal of NeuroscienceSemantic encoding and retrieval in the left inferior prefrontal cortex: a functional MRI study of task difficulty and process specificity
921 Citations1995Jonathan B. Demb, JE Desmond +4 more
Findings suggest that the left inferior prefrontal cortex (LIPC) is part of a semantic executive system that contributes to the on-line retrieval of semantic information.
Electroencephalography and Clinical NeurophysiologyEvent-related potentials, lexical decision and semantic priming
841 Citations1985Shlomo Bentin, Gregory McCarthy +1 more
ERPs were recorded during a lexical decision task in order to investigate electrophysiological concomitants of semantic priming and P300, N200, and N400 differences were observed at locations over both hemispheres and were maximal in the centroparietal region.
Journal of Cognitive NeuroscienceThe Processing Nature of the N400: Evidence from Masked Priming
793 Citations1993Colin Brown, Peter Hagoort
This paper compared the effect of masked and unmasked presentations of a prime on the N400 to a following target, and indicated that the N 400 is not a manifestation of lexical access processes, but reflects aspects of semantic integration processes.
Electroencephalography and Clinical NeurophysiologySpatial sampling of head electrical fields: the geodesic sensor net
761 Citations1993Don M. Tucker
In studying brain electrical activity from scalp sensors (electrodes), the optimal measurement would sample the potential field over the entire surface of the braincase, with a sufficient density to avoid spatial aliasing of the surface electrical fields.
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460 Citations1994Mark Beeman, Rhonda B. Friedman +4 more
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389 Citations1986David A. Balota, Robert F. Lorch
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386 Citations1995Anna C. Nobre, Gregory McCarthy
The AMTL field potential was diminished by semantic priming, and was larger for words with semantic content than for words serving grammatical function, and the N400 scalp event-related potential has been shown to respond in the same manner to these task manipulations.
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323 Citations1996Peter Hagoort, Colin Brown +1 more
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321 Citations1994Anna C. Nobre, Gregory McCarthy
The isolation of this novel language-related ERF' that is sensitive to semantic manipulations has important consequences for temporal and mechanistic aspects of theories of language processing.
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284 Citations1998Markus Kiefer, Frank Marzinzik +3 more
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Proceedings of the National Academy of SciencesScalp electrical potentials reflect regional cerebral blood flow responses during processing of written words.
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Journal of Verbal Learning and Verbal BehaviorThe range of automatic spreading activation in word priming
210 Citations1983Annette M.B. de Groot
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199 Citations1991Paolo Maria Rossini
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197 Citations1997Yalchin G. Abdullaev, Michael I. Posner
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The results imply that hemisphere differences for processing abstract and concrete words may arise only after lexical access has occurred, when semantic information retrieved from the lexicon becomes available for subsequent processing.
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94 Citations1995François Guillem, Bernard N’Kaoua +2 more
To isolate the anatomical locus of the neural activity most important for generating or modulating the scalp-recorded N400 and P600 components elicited during continuous recognition memory tasks, intracranial event-related potentials were recorded from medial and lateral aspects of the temporal, frontal, parietal, and occipital lobes in 25 patients undergoing stereoelectroencephalography for seizure localization.
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87 Citations1995Manfred Spitzer, Kenneth K. Kwong +3 more
Data suggest the existence of multiple maps coding high-level representations of objects, such that meaningful distinctions, at least in part, govern the physical distribution of cortical semantic storage.
PubMedNeuroanatomy, circuitry and plasticity of word reading.
74 Citations1999Michael I. Posner, Ya. G. Abdullaev +2 more
Results in brain areas active during reading of words and sentences are summarized and how acquisition and practice of the skill might alter the circuitry involved is suggested.
Mathematical CognitionThe Time Course of Parietal Activation in Single-digit Multiplication: Evidence from Event-related Potentials
72 Citations1997Markus Kiefer, Stanislas Dehaene
Electrophysiological, neuropsychological, and brain-imaging data suggest that left inferior parietal areas are involved in mental calculation, andEvent-related potentials ERPs were used to examine the organization of brain activations during single-digit multiplication, suggesting that simple multiplication problems may involve a short-lived activation in the left inferiorParietal cortex, whereas complex problems may require longer processing.
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Language and SpeechElectrophysiological Studies of Visual Word Perception, Lexical Organization, and Semantic Processing: A Tutorial Review
61 Citations1989Shlomo Bentin
Event-related potentials (ERPs) provide a relatively new tool that complements behavioral measures of word recognition and enable the researcher to examine word perception and reading in more natural situations, without time constraints and overt responses.
Semantic Priming in the Intact Brain: Separate Roles for the Right and Left Hemispheres?
45 Citations1988Christine Chiarello
Evidence is considered about lateralized lexical processing in the intact brain obtained when the visual pathways leading to one cerebral hemisphere are selectively stimulated [the visual half-field (VHF) method)].
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31 Citations1987Margit Koemeda-Lutz, Rudolf Cohen +1 more
Verbal labels denoting the sorting criterion and added to the picture presentation did not affect the performance of the right hemisphere controls but significantly improved that of the aphasics.
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27 Citations1996Manfred Spitzer, Matthias E. Bellemann +6 more
Functional magnetic resonance imaging was used to investigate the relation between brain activation and the processing of word associations and represents a powerful tool for the study of brain-behavior interaction.
Neuroscience LettersNeuronal activity in frontal speech area 44 of the human cerebral cortex during word recognition
18 Citations1991N.P. Bechtereva, Yalchin G. Abdullaev +1 more
The present finding provides the first demonstration of neuronal mechanisms in frontal language cortex and evidences that both consecutive and parallel processing of these speech signs occur in neuronal activity of this area.
Brain and LanguageDisorders of classificatory activity in aphasia
17 Citations1986Guido Gainotti, Sergio Carlomagno +2 more
Results were for the most part in line with expectations because aphasics scored worse than normal controls and nonaphasic brain-damaged patients and within the aphasic patients the worst results were obtained by subjects presenting clear signs of semantic-lexical disintegration.