An Approach to Catalytic Enantioselective Protonation of Prochiral Lithium Enolates
Tetrahedron LettersPublished 1 October 1997
Pierre Rivière, Kenji Koga
Citations48
SJR quartileQ3
SJR score0.33
SNIP0.43
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Abstract
Protonation of prochiral lithium enolates (4), prepared from racemic 2-substituted-1-tetralones (2) via their silyl enol ethers (3), with excess succinimide in the presence of lithium bromide and 0.2 equivalent of a chiral tetradentate amine ((R)-1) in toluene at −78 °C gave optically active 2 in up to 83% ee. © 1997 Elsevier Science Ltd.
Keywords
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