The complementary structure of deoxyribonucleic acid
Proceedings of the Royal Society of London A Mathematical and Physical SciencesPublished 7 April 1954
Francis Crick, James D. Watson
Citations392
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TL;DR
This paper describes a possible structure for the paracrystalline form of the sodium salt of deoxyribonucleic acid that consists of two DNA chains wound helically round a common axis, and held together by hydrogen bonds between specific pairs of bases.
Abstract
Abstract This paper describes a possible structure for the paracrystalline form of the sodium salt of deoxyribonucleic acid. The structure consists of two DNA chains wound helically round a common axis, and held together by hydrogen bonds between specific pairs of bases. The assumptions made in deriving the structure are described, and co-ordinates are given for the principal atoms. The structure of the crystalline form is discussed briefly.
Keywords
ChemistryMaterials ScienceBiochemistry, Genetics and Molecular Biology
NatureMolecular Structure of Nucleic Acids: A Structure for Deoxyribose Nucleic Acid
13,208 Citations1953James Dewey Watson, Francis Crick
The determination in 1953 of the structure of deoxyribonucleic acid (DNA), with its two entwined helices and paired organic bases, was a tour de force in X-ray crystallography and opened the way for a deeper understanding of perhaps the most important biological process.
Proceedings of the National Academy of SciencesThe structure of proteins: Two hydrogen-bonded helical configurations of the polypeptide chain
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This work has used information about interatomic distances, bond angles, and other configurational parameters to construct two reasonable hydrogen-bonded helical configurations for the polypeptide chain; it is likely that these configurations constitute an important part of the structure of both fibrous and globular proteins, as well as of syntheticpolypeptides.
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Proceedings of the National Academy of SciencesA Proposed Structure For The Nucleic Acids
246 Citations1953Linus Pauling, Robert B. Corey
The proposed structure for the Nucleic Acids is based on X-ray diffraction analysis of Na6(CO3, Na3SO4, Na2SO3, and Na2CO4 using a Higgs boson-like structure.
Acta CrystallographicaThe structure of sodium thymonucleate fibres. II. The cylindrically symmetrical Patterson function
102 Citations1953Rosalind Franklin, R.G. Gosling
Acta CrystallographicaThe structure of pyrimidines and purines. II. A determination of the structure of adenine hydrochloride by X-ray methods
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Biochimica et Biophysica ActaElectron microscopy of sodium desoxyribonucleate by use of a new freeze-drying method
36 Citations1952Robley C. Williams
A new method of freeze-drying for the preparation of biological specimens for electron microscopy using micro-volumes of specimen material in the form of spray droplets which are rapidly cooled upon a surface in good thermal contact with a relatively massive thermal reservoir.
Biochimica et Biophysica ActaAn X-ray diffraction investigation of aqueous systems of desoxyribonucleic acid (Na salt)
32 Citations1951Dennis P. Riley, Gérald Oster
Aqueous systems of desoxyribonucleic acid, over a range of concentrations from about 0.03 to 1.8 g/ml (2% to 100% by volume), are submitted to X-ray diffraction analysis and appear to be really crystalline and, on further dilution, the systems are paracrystalline over a wide range.
Biochimica et Biophysica ActaThe electron microscopy of sodium desoxyribonucleate
28 Citations1953H. Kahler, Bolivar J. Lloyd
Electron micrographs of sodium desoxyribonucleate have been obtained from which a diameter of the fiber of 15 ± 5 A has been deduced and similar measurements on nucleo-protein from calf thymus were made from which an diameter of 25 A was deduced.
NatureNucleic Acids of Rickettsiæ
25 Citations1952G.R. Wyatt, Shira Cohen
It is pointed out that the deoxyribonucleic acid of Q-fever rickettsiæ grown in embryonated eggs is closely similar in composition to that of chick embryos, and the possibility that ricketsiæ may incorporate nucleic acid directly from their host is mentioned.
Journal of the Chemical Society (Resumed)406. Deoxyribonucleosides and related compounds. Part II. A proof of the furanose structure of the natural 2-deoxyribonucleosides
20 Citations1950D. M. Brown, B. Lythgoe