Suberosenone, a new cytotoxin from Subergorgia suberosa
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TL;DR
Sberosenone, the first quadrone-class sesquiterpene from the marine biosphere, exhibited relatively potent cytotoxicity to solid tumor lines in comparison to leukemia lines in the NCI's 60 cell line in vitro screen.
Abstract
The organic extract of the gorgonian Subergorgia suberosa was found to contain a novel cytotoxic sesquiterpene, suberosenone (1), as well as two known piscicidal sesquiterpenes, buddledins C and D. The structure of 1 was defined by spectral methods, including 1D and 2D NMR experiments. Suberosenone, the first quadrone-class sesquiterpene from the marine biosphere, exhibited relatively potent cytotoxicity to solid tumor lines in comparison to leukemia lines in the NCI's 60 cell line in vitro screen.