The combination of NMDA antagonism and morphine produces profound antinociception in the rat dorsal horn
Brain ResearchPublished 1 February 1992
Victoria Chapman, Anthony H. Dickenson
Citations198
SJR quartileQ2
SJR score0.85
SNIP0.72
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TL;DR
Dorsal horn nociceptive neurones exhibit wind up, a frequency dependent potentiation of their responses to repeated C-fibre stimulation, but the combination of intrathecal morphine and 7-chlorokynurenate abolishes both the input and wind up of these neurones.
Abstract
Dorsal horn nociceptive neurones exhibit wind up, a frequency dependent potentiation of their responses to repeated C-fibre stimulation. Intrathecal morphine (5 micrograms) significantly reduces the initial responses of the neurones but not wind up whereas the reverse is true for N-methyl-D-aspartate (NMDA) antagonists. The combination of intrathecal morphine (5 micrograms) and 7-chlorokynurenate (2.5 micrograms), an antagonist at the glycine site of the NMDA receptor, abolishes both the input and wind up of these neurones.
Keywords
MedicineBiochemistry, Genetics and Molecular Biology
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