Variation in breast cancer subtypes with age and race/ethnicity
Critical Reviews in Oncology/HematologyPublished 4 October 2009
Carol Parise, Katrina Bauer, Vincent Caggiano
Citations112
SJR quartileQ1
SJR score1.82
SNIP1.40
Generate an AI Snapshot to get a quick, structured summary of this paper.
Study Snapshot
ObjectiveStudy objective
MethodsResearch methodology
PopulationPopulation studied
Sample sizeSample sizes
OutcomesStudy outcomes here
ResultsStudy results comes here
LimitationsResearch study limitations comes here
A concise AI-generated summary of the paper will appear here once you click Generate AI Snapshot.
TL;DR
The ER/PR/HER2 subtypes vary with age and differences in this variation depend on race, and it is important to define breast cancer using the ER/ PR/ HER2 subtype and the significance of age and race should not be overlooked.
Abstract
The ER/PR/HER2 subtypes vary with age and differences in this variation depend on race. It is important to define breast cancer using the ER/PR/HER2 subtype and the significance of age and race should not be overlooked.
Keywords
MedicineBiochemistry, Genetics and Molecular Biology
AJCC Cancer Staging Manual
17,372 Citations2016
NatureMolecular portraits of human breast tumours
16,304 Citations2000Charles M. Perou, Thérese Sørlie +16 more
Variation in gene expression patterns in a set of 65 surgical specimens of human breast tumours from 42 different individuals were characterized using complementary DNA microarrays representing 8,102 human genes, providing a distinctive molecular portrait of each tumour.
Proceedings of the National Academy of SciencesGene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications
10,939 Citations2001Thérese Sørlie, Charles M. Perou +15 more
Survival analyses on a subcohort of patients with locally advanced breast cancer uniformly treated in a prospective study showed significantly different outcomes for the patients belonging to the various groups, including a poor prognosis for the basal-like subtype and a significant difference in outcome for the two estrogen receptor-positive groups.
AJCC Cancer Staging Manual
6,380 Citations2002American Joint Committee on Cancer, Greene, Frederick L. +4 more
Purposes and Principles of Cancer Staging and End-Results Reporting are explained.
JAMARace, Breast Cancer Subtypes, and Survival in the Carolina Breast Cancer Study
3,834 Citations2006Lisa A. Carey, Charles M. Perou +15 more
Basal-like breast tumors occurred at a higher prevalence among premenopausal African American patients compared with postmenopausal American and non-African American patients in this population-based study, and their associations with tumor size, axillary nodal status, mitotic index, nuclear pleomorphism, combined grade, p53 mutation status, and breast cancer-specific survival were examined.
DefinitionsInternational Classification of Diseases for Oncology
3,826 Citations2020National Cancer Institute
CancerDescriptive analysis of estrogen receptor (ER)‐negative, progesterone receptor (PR)‐negative, and HER2‐negative invasive breast cancer, the so‐called triple‐negative phenotype
2,083 Citations2007Katrina Bauer, Monica Brown +3 more
This work has shown that the triple‐negative phenotype is important because of its relation to the basal‐like subtype of breast cancer.
Cancer Causes & ControlSocioeconomic status and breast cancer incidence in California for different race/ethnic groups
965 Citations2001Kathleen J. Yost, Carin Perkins +3 more
SES was positively related to breast cancer incidence, and this effect was stronger for Hispanics and Asian/others than for whites and blacks, which is consistent with similar findings for the Los Angeles area but differ from previous results for the San Francisco Bay area.
Breast Cancer ResearchHormone receptor status, tumor characteristics, and prognosis: a prospective cohort of breast cancer patients
810 Citations2007Lisa K. Dunnwald, Mary Anne Rossing +1 more
The higher relative mortality risks identified among ER-/PR- patients with small or low-grade tumors raise the question of whether there may be a beneficial role for adjuvant chemotherapy in this population of women.
JNCI Journal of the National Cancer InstituteEthnicity and Breast Cancer: Factors Influencing Differences in Incidence and Outcome
689 Citations2005Rowan T. Chlebowski, Zhao Chen +10 more
Differences in breast cancer incidence rates between most racial/ethnic groups were largely explained by risk factor distribution except in African Americans, however, breast cancers in African American women more commonly had characteristics of poor prognosis, which may contribute to their increased mortality after diagnosis.
JNCI Journal of the National Cancer InstituteTumor Characteristics and Clinical Outcome of Elderly Women With Breast Cancer
680 Citations2000Sami Diab
In women 55 years old or older, advancing age is associated with more favorable tumor biology, and breast cancer survival in older women is similar to survival in the general population irrespective of disease status.
CancerDifferences in breast carcinoma characteristics in newly diagnosed African–American and Caucasian patients
608 Citations2007Gloria J. Morris, Sashi Naidu +9 more
Breast carcinomas in African–American patients appear to be more aggressive than in Caucasian patients due to multifactorial differences, and these differences may be related to race, ethnicity, or both.
JNCI Journal of the National Cancer InstituteRisk Factors for Breast Cancer According to Estrogen and Progesterone Receptor Status
541 Citations2004Graham A. Colditz, B. A. Rosner +3 more
Incidence rates and risk factors for breast cancer differ according to ER and PR status, and breast cancer cases should be divided according to the ER andPR status of the tumor.
Journal of Clinical OncologyMeta-Analysis of Survival in African American and White American Patients With Breast Cancer: Ethnicity Compared With Socioeconomic Status
368 Citations2006Lisa A. Newman, Kent A. Griffith +4 more
The pooled analysis demonstrated that African American ethnicity is a significant and independent predictor of poor outcome from breast cancer, even after accounting for socioeconomic status by conventional measures.
The Breast JournalBreast Cancer Subtypes as Defined by the Estrogen Receptor (ER), Progesterone Receptor (PR), and the Human Epidermal Growth Factor Receptor 2 (HER2) among Women with Invasive Breast Cancer in California, 1999-2004
321 Citations2009Carol Parise, Katrina Bauer +2 more
There are considerable differences in survival, demographics, and tumor characteristics among the eight subtypes and it is recommended to report breast cancer as an ER/PR/HER2 subtype and precisely documenting demographic and tumors characteristics.
Breast Cancer ResearchTriple-negative breast cancers are increased in black women regardless of age or body mass index
249 Citations2009Lesley Stead, Timothy L. Lash +8 more
Black women of diverse background have 3-fold more Tneg tumours than non-black women, regardless of age and BMI, which likely contributes to black women's unfavorable breast cancer prognosis.
Journal of Clinical OncologyEstrogen- and Progesterone-Receptor Status in ECOG 2197: Comparison of Immunohistochemistry by Local and Central Laboratories and Quantitative Reverse Transcription Polymerase Chain Reaction by Central Laboratory
236 Citations2008Sunil Badve, Frederick L. Baehner +13 more
Although ER expression is marginally associated with relapse in ER-positive patients treated with chemohormonal therapy, recurrence score is a highly significant predictor of recurrence.
CancerHormone receptor status and survival in a population‐based cohort of patients with breast carcinoma
230 Citations2005Victor R. Grann, Andrea B. Troxel +4 more
The objective of this study was to assess hormone receptor status as an independent predictor of survival in a population‐based cohort of women with breast carcinoma who were followed for up to 11 years.
CancerThe role of human epidermal growth factor receptor 2 in the survival of women with estrogen and progesterone receptor‐negative, invasive breast cancer: The California Cancer Registry, 1999–2004
223 Citations2008Monica Brown, Alex Tsodikov +3 more
The authors quantified the contribution of HER2 as well as demographic and tumor characteristics to the survival of women with TN tumors, DN tumors, and other breast cancers (OBC).
The International Journal of Biochemistry & Cell BiologyAge-associated biomarker profiles of human breast cancer
124 Citations2002Serenella Eppenberger‐Castori, Dan H. Moore +5 more
The hypothesis that breast cancer biology is significantly affected by patient age is supported, in particular, breast tumors arising in older patients have slower growth rates, are more likely to be ER-positive, and are lesslikely to be p53- positive, EGFR-positive or ErbB2-positive.
Breast Cancer Research and TreatmentAxillary lymph node status of operable breast cancers by combined steroid receptor and HER-2 status: triple positive tumours are more likely lymph node positive
91 Citations2008Ben Van Calster, Isabelle Vanden Bempt +21 more
The authors' data provide insight into the natural history of triple positive breast carcinomas, with triple positive tumours more likely ALN positive than those with another steroid receptor and HER-2 status.
CancerHigh prevalence of triple‐negative tumors in an urban cancer center
86 Citations2008Mary Jo Lund, Eboneé N. Butler +8 more
Investigation of breast cancer subgroups among patients in an urban cancer center serving a multiracial, low socioeconomic population found age, race, and socioeconomic status have been associated with triple‐negative tumors (TNT).
Breast Cancer Research and TreatmentAssociation between HER-2/neu and the progesterone receptor in oestrogen-dependent breast cancer is age-related
62 Citations2005Huei‐Jean Huang, Patrick Neven +8 more
An age-related inverse relationship between HER-2/neu and PR is observed only in women age >45 years but not in women aged ≤45 years, confirming a lower response to anti-oestrogens if ER+.
CancerRacial disparities in breast cancer outcome
49 Citations2007Romano Demicheli, Michael Retsky +4 more
It is suggested that the components of the AA versus CA disparity not attributable to socioeconomic factors are a particular case of the more general issue of host‐tumor interaction and that epidemiologic and clinical views are complementary; each is observing biologic parameters, which are not completely captured by the other.
JNCI MonographsFactors Used to Select Adjuvant Therapy of Breast Cancer in the United States: an Overview of Age, Race, and Socioeconomic Status
41 Citations2001Hyman B. Muss
Age, race, and socioeconomic status all play a role in decisions regarding breast cancer adjuvant therapy, while in very young women breast cancer may have a poorer prognosis, even when adjusted for disease stage and other variables.
Breast Cancer Research and TreatmentAge interacts with the expression of steroid and HER-2 receptors in operable invasive breast cancer
16 Citations2007Patrick Neven, Ben Van Calster +18 more
A qualitative interaction between age and expression of steroid and HER-2 receptors is found, suggesting a strong age-related selective growth advantage for breast tumour cells belonging to the ER+PR+HER-2+ subgroup.
Critical Reviews in Oncology/HematologyP.6 Breast cancer subtypes in elderly women
1 Citations2007Vincent Caggiano, Matthew Brown +2 more
Overall five-year relative survival was best in patients >70 years of age, and important differences in race/ethnicity, stage at diagnosis, and tumor grade were noted with increasing age.