On the role of endogenous opioid peptides: Failure of naloxone to influence shock escape threshold in the rat
Life SciencesPublished 1 March 1976
Avram Goldstein, Gordon T. Pryor, Leon S. Otis, Ferol F. Larsen
Citations138
SJR quartileQ1
SJR score1.31
SNIP1.07
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TL;DR
The data offer no support to the hypothesis that an endogenous opioid modulates responsiveness to pain and discomfort, and rats treated with doses of naloxone sufficient to block morphine analgesia showed no change in the threshold for escape from foot shock.
Abstract
Rats treated with doses of naloxone sufficient to block morphine analgesia showed no change in the threshold for escape from foot shock. The data offer no support to the hypothesis that an endogenous opioid modulates responsiveness to pain and discomfort.
Keywords
MedicineNeuroscienceBiochemistry, Genetics and Molecular Biology
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