Tumor spectrum analysis in p53-mutant mice
Current BiologyPublished 1 January 1994
Tyler Jacks, Lee Ann Remington, Bart O. Williams, Earlene M. Schmitt, Shlomit Halachmi, Roderick T. Bronson
Citations2,064
SJR quartileQ1
SJR score2.71
SNIP1.83
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TL;DR
It is reaffirm that p53 function is not required for normal mouse development and conclude that p 53 status can strongly influence tumor latency and tissue distribution.
Abstract
We reaffirm that p53 function is not required for normal mouse development and conclude that p53 status can strongly influence tumor latency and tissue distribution.
Keywords
MedicineBiochemistry, Genetics and Molecular Biology
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Germ line p53 mutations have been detected in all five LFS families analyzed and can now be examined in additional families with LFS, and in other cancer patients and families with clinical features that might be attributed to the mutation.
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It is demonstrated that an oncogene, specifically the adenovirus E1A gene, can sensitize fibroblasts to apoptosis induced by ionizing radiation, 5-fluorouracil, etoposide, and adriamycin, and the involvement of p53 in the apoptotic response suggests a mechanism whereby tumor cells can acquire cross-resistance to anticancer agents.
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It is reported here that young heterozygous mice do not appear abnormal and do not develop retinoblastoma at a detectable frequency, however, homozygous mutant embryos fail to reach term and show a number of abnormalities in neural and haematopoietic development.
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918 Citations1992S E Kern, JA Pietenpol +4 more
C Cotransfection experiments showed that wild-type p53 activated the expression of genes adjacent to a p53 DNA binding site, which correlated with DNA binding in vitro and provided a basis for the selection of such mutants during tumorigenesis.
DevelopmentTeratocarcinomas and Embryonic Stem Cells: A Practical Approach
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The results allowed us to assess the importance of knowing the carrier and removal status of canine coronavirus, as a source of infection for other animals, not necessarily belonging to the same breeds.
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900 Citations1993Dirk P. Dittmer, Sibani Pati +6 more
These data demonstrate a gain of function associated with p53 mutations in addition to the loss of function shown previously to be associated with mutations in this tumour suppressor gene.
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877 Citations1993M Debbas, Eileen White
The p53 protein may function as a tumor suppressor by initiating a cell suicide response to deregulation of growth control by E1A, and the E1B 19K and 55K proteins provide separate mechanisms that disable the cell suicide pathway of p53.
Trends in GeneticsTeratocarcinomas and embryonic stem cells: A practical approach
782 Citations1987Robb Krumlauf
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Quantitative improvements of transformation frequencies are associated with the higher expression levels of altered p53 protein that are provided by having one of the p53 introns in the transforming plasmid.
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520 Citations1992Edward Seto, Anny Usheva +6 more
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425 Citations1986Achim Gossler, Thomas Doetschman +3 more
This study demonstrates that blastocyst-derived embryonic stem cells (ES cells) can be used as a vehicle for transgenesis, and the introduced neomycin phosphotransferase (neo) gene is stably transmitted through several generations with no apparent loss in G418 resistance.
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362 Citations1989Douglas Hanahan
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The EMBO JournalAnalysis of the gene coding for the murine cellular tumour antigen p53.
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A genomic clone containing the functional gene for the murine p53 cellular tumour antigen was isolated and structurally characterised, and suggestive similarities were found to exist between p53 and the protein product of the myc oncogene.
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The EMBO JournalPrecise epitope mapping of the murine transformation‐associated protein, p53.
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This approach enabled us to map accurately the binding sites of seven different monoclonal antibodies, demonstrating four distinct antigenic sites on p53, and a synthetic peptide was constructed corresponding to the predicted amino acid sequence of one of these epitopes.