Clinical experience with implant contraception
ContraceptionPublished 1 October 1978Open access
Elsimar Metzker Coutinho
Citations40
SJR quartileQ1
SJR score1.33
SNIP1.15
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TL;DR
Subdermal implants of polysiloxane (Silastic) capsules containing a number of synthetic progestagens have been studied in clinical trials to determine their contraceptive effectiveness and acceptability and indicate in general a high rate of effectiveness, as well as acceptability.
Abstract
A time-integrated entanglement mass in polymer melts was determined from various measurable quantities. Taking the critical mass as a definition of the 'reptational' entanglement mass, it was found that all methods based on time-resolved quantities give the same result. It was observed that such a value differs, beyond error bars, from that obtained from the plateau modulus, which is a time-integrated quantity. The possible reasons for the plateau modulus discrepancy were also discussed.
Keywords
Immunology and MicrobiologyMedicine
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Although the advantages of the IUD weigh heavily at any level of economic and social development, they are particularly applicable in those situations where the population is not accustomed to contraceptive practice, is economically disadvantaged, has limited educational opportunities, and where medical services are in short supply.
American Journal of Obstetrics and GynecologyAcceptability of long-term contraceptive steroid administration in humans by subcutaneous Silastic capsules
49 Citations1969Howard J. Tatum, Elsimar Metzker Coutinho +2 more
Clinical, histologic, and cytologic data suggested that ovulation was not suppressed by four or fewer implants, and there was frequent inhibition of ovulation in the patients bearing six implants.
ContraceptionLongterm contraception by subcutaneous silasticR capsules containing megestrol acetate
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Contraceptive effectiveness and acceptability of subcutaneous silastic capsules containing Megestrol Acetate were evaluated and data suggest that in most patients in both groups conception is prevented without inhibition of ovulation.
American Journal of Obstetrics and GynecologyUse of subcutaneous Silastic capsules for long-term steroid contraception
36 Citations1970S. Tejuja
Menstrual pattern and histologic examination of the endometrium indicated that ovulation was not inhibited by 3 or fewer implants, and it is suggested that further trials with 3 or 4 implants would help elucidate the dose and acceptability of this simple method for long-term conception control.
Fertility and SterilityOne-Year Contraception with Norgestrienone Subdermal Silastic Implants
35 Citations1974Elsimar Metzker Coutinho, Rita da Silva
Silastic capsules of Norgestrienone 17 alpha-ethinyl-17-hydroxy-estra-4 9 11-trien-3-one were inserted subcutaneously in the anterior forearm or in the upper gluteal region of 503 women of childbearing age, finding contraceptive effectiveness was high and lasted a minimum of 10 and 12 months respectively.
ContraceptionContraceptive effectiveness of silastic
30 Citations1975Elsimar Metzker Coutinho, Rita da Silva +3 more
The long-term contraceptive effectiveness of subdermal silastic implants containing 30-40 mg of the progestin R-2323 (13-ethyl-17 alpha ethinyl-17 hydroxy-gona-4, 9,11-trien-3-one), was studied in 531 women.
ContraceptionFurther studies on long-term contraception by subcutaneous silasticR∗ capsules containing megestrol acetate
27 Citations1972Elsimar Metzker Coutinho, Carlos E.R. Mattos +4 more
The contraceptive effectiveness of megestrol acetate (M.A.) implants was evaluated in 126 parous young women and three pregnancies occurred in patients observed for up to 15 months for over 1,440 cycles.
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25 Citations1971Horacio B. Croxatto, Soledad Dı́az +4 more
It is concluded that these implants at the doses tested in this study can reduce fertility for periods up to 1 year but their acceptability as a contraceptive method in humans is limited mainly by their low effectiveness and the increased medical risk associated with method failures.
ReproductionEXCRETION OF [6-14C]MEGESTROL ACETATE (6 METHYL-17 ACETOXYPREGNA-4,6 DIENE, 3,20 DIONE) RELEASED FROM SUBCUTANEOUS SILASTIC IMPLANTS IN WOMEN
24 Citations1970Elsimar Metzker Coutinho, D. A. M. FERREIRA +2 more
The mean urinary excretion of megestrol acetate was highest during the week following the insertion of the 2 implants, and rates declined most rapidly during the first 30 days.