Thymus, peripheral lymphoid tissues and immunological responsiveness of the pituitary dwarf mouse
Cellular and Molecular Life SciencesPublished 1 April 1967
Carlo Baroni
Citations74
SJR quartileQ1
SJR score2.30
SNIP1.48
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Abstract
L'autore ha studiato la morfologia del sistema linforeticolare e lo stato di reattività immunitaria del topo Snell/Bagg con nanismo ereditario preipofisario. È stata riscontrata una notevole ipoplasia di tutto il sistema linforeticolare ed una severa diminuzione della capacità anticorpopoietica la cui causa viene fatta risalire con ogni probabilità al grave stato di deficit timico congenito. Si prospetta che il topo nano ipofisario sia portatore di una sindrome analoga a quella sperimentalmente indotta mediante timectomia neonatale.
Keywords
Medicine
Proceedings of the Royal Society of London. Series B, Biological sciencesEffect of neonatal thymectomy on the immunological responsiveness of the mouse
378 Citations1962J. F. A. P. Miller
It is concluded that, during very early life, the thymus produces the progenitors of immunologically competent cells which mature and migrate to other sites and present evidence does not exclude the production by the youngThymus of a humoral factor necessary to the maturation or proliferation of lymphocytes elsewhere in the body.
NatureEffect of Thymectomy in Adult Mice on Immunological Responsiveness
182 Citations1965J. F. A. P. Miller
Evidence is given for a continuing immunological function of the thymus through adult life by showing that thymectomy in adult immunologically tolerant mice prevented the reappearance of reactivity with respect to that antigen.
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163 Citations1963Raphael H. Levey, Nathan Trainin +1 more
NatureDelayed Effect of Thymectomy in Adult Life on Immunological Competence
136 Citations1965Donald Metcalf
It is suggested that whole-body irradiation by causing cell damage and repopulation in haemopoietic organs may merely accelerate a process which occurs continually throughout life, albeit at a much slower rate.
NatureThymus and the Production of Antibody-plaque-forming Cells
74 Citations1965J. F. A. P. Miller, P. M. De Burgh +1 more
Evidence is presented here to show that thymectomy practically inhibits the development of the capacity to produce antibody-plaque-forming cells following the injection of sheep erythrocytes.