Estimating the rate of mother-to-child transmission of HIV. Report of a workshop on methodological issues Ghent (Belgium), 17–20 February 1992
AIDSPublished 1 August 1993
François Dabis, Philippe Msellati, David Dunn, Philippe Lepage, Marie‐Louise Newell, Catherine Peckham
Citations130
SJR quartileQ1
SJR score1.21
SNIP0.90
Generate an AI Snapshot to get a quick, structured summary of this paper.
Study Snapshot
ObjectiveStudy objective
MethodsResearch methodology
PopulationPopulation studied
Sample sizeSample sizes
OutcomesStudy outcomes here
ResultsStudy results comes here
LimitationsResearch study limitations comes here
A concise AI-generated summary of the paper will appear here once you click Generate AI Snapshot.
TL;DR
A common methodology was developed and can now be applied to all studies with sufficient follow-up and comparisons made between transmission rates, essential for assessing determinants of transmission and for the development of a common approach for the evaluation of interventions aimed at reducing or interrupting MTCT of HIV.
Abstract
The methodology can now be applied to all studies with sufficient follow-up and comparisons made between transmission rates. This step is essential for assessing determinants of transmission and for the development of a common approach for the evaluation of interventions aimed at reducing or interrupting MTCT of HIV.
Keywords
Immunology and MicrobiologyMedicineHealth Professions
The LancetRisk of human immunodeficiency virus type 1 transmission through breastfeeding
807 Citations1992David Dunn, Marie‐Louise Newell +2 more
New England Journal of MedicineA Prospective Study of Infants Born to Women Seropositive for Human Immunodeficiency Virus Type 1
513 Citations1989Stéphane Blanche, C Rouzioux +16 more
It is concluded that approximately one third of the infants born to seropositive mothers will have evidence of HIV-1 infection or of AIDS by the age of 18 months, and that about one fifth of this group will have died.
New England Journal of MedicinePerinatal Transmission of the Human Immunodeficiency Virus Type 1 to Infants of Seropositive Women in Zaire
462 Citations1989Robert W. Ryder, Wato Nsa +16 more
It is concluded that the mortality rates among children of seropositive mothers are high regardless of socioeconomic status, and that perinatal transmission of HIV-1 has a major adverse effect on infant survival in Kinshasa.
New England Journal of MedicineSurvival in Children with Perinatally Acquired Human Immunodeficiency Virus Type 1 Infection
433 Citations1989G. B. Scott, Cecelia Hutto +6 more
The LancetRisk factors for mother-to-child transmission of HIV-1
422 Citations1992European Collaborative Study
The balance of evidence suggests that mothers with established infection can transmit HIV infection through breastmilk, although the relative importance of this route remains to be defined.
New England Journal of MedicinePostnatal Transmission of Human Immunodeficiency Virus Type 1 from Mother to Infant
361 Citations1991Philippe Van de Perre, Arlette Simonon +10 more
A prospective cohort study in Kigali, Rwanda, of 212 mother—infant pairs who were seronegative for HIV-1 at delivery and after a mean follow-up of 16.6 months, 16 of the 212 mothers became seropositive for HIV in their infants, and one infant was excluded from the analysis because of a positive test on the blood sample obtained at birth.
PubMedChildren born to women with HIV-1 infection: natural history and risk of transmission. European Collaborative Study.
326 Citations1991Ades Ae, Marie‐Louise Newell +1 more
The LancetChildhood deaths in Africa: uses and limitations of verbal autopsies
298 Citations1992R.W. Snow, Robert W. Snow +13 more
Sensitivity of the VA technique was greater than 75% for measles, neonatal tetanus, malnutrition, and trauma-related deaths; however, malaria, anaemia, acute respiratory-tract infection, gastroenteritis, and meningitis were detected with sensitivities of less than 50%.
Journal of Chronic DiseasesEstimation of confidence limits for the cumulative probability of survival in life table analysis
288 Citations1978Kenneth J. Rothman
Cutler and Ederer illustrated how the life table approach could provide considerably more information on 5-yr survival than would be available from only those subjects followed for at least 5 yr.
The LancetCurrent and future dimensions of the HIV/AIDS pandemic in women and children
266 Citations1990Jerome H. Chin
During the 1990s, not only can hundreds of thousands of paediatric AIDS cases be expected, but also more than a million uninfected children will be orphaned because their HIV-infected mothers and fathers will have died from AIDS.
The LancetInfective and anti-infective properties of breastmilk from HIV-1-infected women
228 Citations1993Philippe Van de Perre, Arlette Simonon +8 more
The combination of HIV-1-infected cells in breastmilk and a defective IgM response was the strongest predictor of infection, and IgM and IgA anti-HIV-1 in Breastmilk may protect against postnatal transmission of the virus.
The LancetINFANTS BORN TO MOTHERS SEROPOSITIVE FOR HUMAN IMMUNODEFICIENCY VIRUS
206 Citations1987J Mok, Anita De Rossi +4 more
It is suggested that the risk of AIDS/ARC is higher in infants born to mothers who have AIDS symptoms during pregnancy and mode of delivery or breast-feeding.
BMJPerinatal transmission of HIV-I in Zambia.
150 Citations1989S K Hira, J Kamanga +5 more
Vertical transmission from infected mothers to their babies is high in Zambia and prognosis is poor for the babies, and perinatal transmission and paediatric AIDS must be reduced by screening young women and counselling those positive for HIV-I against future pregnancy.
The Journal of PediatricsA hospital-based prospective study of perinatal infection with human immunodeficiency virus type 1
113 Citations1991Cecella Hutto, Wade P. Parks +7 more
No single immunologic or hematologic measure was predictive of infection for all infants at risk for HIV-1 infection who were 6 months of age or younger; as a group, however, infected infants could be distinguished from uninfected index infants by a number of immunologic measures by 6 month of age.
AIDSInfection with HIV as a risk factor for adverse obstetrical outcome
107 Citations1990Marleen Temmerman, Francis A. Plummer +6 more
An association between maternal HIV infection and adverse obstetrical outcome, defined as low birthweight and stillbirth, is suggested.
PubMedTransmission of HIV-1 infections from mothers to infants in Haiti. Impact on childhood mortality and malnutrition. The CDS/JHU AIDS Project Team.
93 Citations1990N A Halsey, R Boulos +8 more
Clinical Infectious DiseasesMaternal-Fetal Transmission of Human Immunodeficiency Virus: A Review of Possible Routes and Cellular Mechanisms of Infection
85 Citations1992G.C. Douglas, Barry F. King
A developmental and cellular approach is used to assess the available clinical and laboratory data pertaining to maternal-fetal HIV transmission and the role of the placenta, particularly the placental trophoblast, on the transmission of HIV.
JAMAEarly Diagnosis of Perinatal HIV Infection by Detection of Viral-Specific IgA Antibodies
82 Citations1991Thomas C. Quinn
Although the HIV-IgA assay had a low sensitivity within the first months of life, the high sensitivity, specificity, and predictive values of this assay demonstrate its utility for the diagnosis of perinatally acquired HIV infection after the third month of age.
AIDSPerinatal transmission of HIV-1
80 Citations1991Philippe Lepage, François Dabis +9 more
The impact of maternal HIV-1 infection on the infant seems limited during the neonatal period, and the frequency of signs and symptoms was not statistically different in the two groups, except for a history of herpes zoster or chronic cough, which was more frequent among HIV-positive women.
American journal of diseases of childrenRate of Transmission of Human Immunodeficiency Virus Type 1 Infection From Mother to Child and Short-term Outcome of Neonatal Infection
78 Citations1990Warren A. Andiman
A continued close follow-up of children in the cohort studied, and others like it, is critical to learn the full range of outcomes of HIV infection in the pediatric population.
AIDSLack of correlation between maternal antibodies to V3 loop peptides of gp120 and perinatal HIV-1 transmission
77 Citations1991Bharat Parekh, Nathan Shaffer +9 more
Sera from 34 HIV-1-seropositive mothers were tested for the presence of antibodies to various regions of the gp120 V3 loop, and results do not support previous reports that epitope-specific antibodies to the V3loop peptides protect against perinatal transmission.
American Journal of EpidemiologyMother–to–Child Transmission of Human Immunodeficiency Virus Type 1 (HIV–1) and Its Determinants: A Cohort Study in Kigali, Rwanda
73 Citations1993Philippe Lepage, Philippe Van de Perre +10 more
Evidence is presented for a higher mother-to-child transmission rate of HIV-1 in children born in Rwanda than in industrialized countries.
The Journal of Infectious DiseasesPediatric AIDS: Problems within Problems
71 Citations1990P. A. Pizzo
Dr Philip A. Pizzo, chief of the Pediatric Branch and head of the Infectious Disease Section of the National Cancer Institute, has made major contributions to the authors' understanding of the diagnosis, management, and treatment of pediatric AIDS.
AIDSMother-child transmission of HIV-1 and infant survival in Brazzaville, Congo
70 Citations1989Marc Lallemant, Sophie Lallemant-Le-Coeur +8 more
The excess of mortality in the babies born to anti-HIV-1-positive mothers is highly significant (P less than 0.001).
PEDIATRICSDiagnosis of Human Immunodeficiency Virus Infection in Infants and Children
59 Citations1990Robert N. Husson, Anne Marie Comeau +1 more
The most significant increases in both HIV infection and AIDS are occurring in users of illicit intravenous drugs, in heterosexual contacts of infected individuals, and in infants born to HIV-infected mothers.
Clinical Infectious DiseasesMother-to-Infant Transmission of Human Immunodeficiency Virus by Breast Milk: Presumed Innocent or Presumed Guilty?
44 Citations1992Philippe Van de Perre, P. Lepage +2 more
This article reviews the virological and epidemiological data available on transmission of the human immunodeficiency virus type 1 (HIV-1) by breast milk and suggests that postpartum HIV-1 seroconversion of a mother may be associated with a high risk of postnatal transmission to offspring via breast milk.
AIDSEvaluation and simplification of the World Health Organization clinical case definition for paediatric AIDS
44 Citations1989Philippe Lepage, Philippe Van de Perre +9 more
A simplified clinical case definition for paediatric AIDS in Africa is proposed with better sensitivity, specificity and PPV than the WHO case definition to develop case definitions useful for epidemiological surveillance and for case management.
PubMedEvaluation of a clinical case definition of AIDS in African children.
36 Citations1987Robert Colebunders, Alan E. Greenberg +7 more
It is suggested that it is more difficult to define AIDS clinically in children than in adults and that the utility of the proposed WHO clinical case definition for pediatric AIDS for surveillance of children's AIDS in Africa is limited.
Epidemiologic ReviewsThe Epidemiology of HIV Infection in Children and Their Mothers—Vertical Transmission
32 Citations1991Laura S. Boylan, Zena Stein
A review of vertical transmission of HIV infection from mothers to infants emphasizes methodological aspects of diagnosis and study and includes all available information up to June 1990, with great need for standard protocols an international database and collaboration on this issue.
PEDIATRICSPerinatal Human Immunodeficiency Virus Infection: Ruminations on Mechanisms of Transmission and Methods of Intervention
32 Citations1992William Borkowsky, Keith Krasinski
PubMedPediatric acquired immunodeficiency syndrome: special considerations for developing nations.
25 Citations1992Thomas C. Quinn, Andrea Ruff +1 more
PubMedReport of a consensus workshop, Siena, Italy, January 17-18, 1992. Early diagnosis of HIV infection in infants.
21 Citations1992Jeanne Albert, Gunnel Biberfeld +3 more
The fact that HIV can be detected in only one-half of infected infants at the time of birth points to the need for further research on the timing of transmission and the natural history of perinatally acquired HIV infection to understand the limitations of current early diagnostic tests and to develop new approaches to overcome these problems.
PubMedReport of a Consensus Workshop, Siena, Italy, January 17-18, 1992. Maternal factors involved in mother-to-child transmission of HIV-1.
10 Citations1992
There are intriguing suggestions that the immunological status of the mother may be influential in preventing or reducing HIV transmission, but this appears to be interrelated with the HIV viral burden and health status ofThe mother and in turn her likelihood to transmit HIV to her offspring.