Blunted Prolactin Responses to <i>d</i>-Fenfluramine in Sociopathy
The British Journal of PsychiatryPublished 1 May 1992
Veronica O’Keane, Eamonn Moloney, Helen O’Neill, Art O'connor, Charles Smith, Timothy G. Dinan
Citations174
SJR quartileQ1
SJR score2.47
SNIP2.17
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TL;DR
Responses were significantly impaired in the patients, suggesting a subsensitivity of certain 5–HT systems in antisocial personality disorder, regardless of recent or ongoing behavioural disturbance.
Abstract
Using a neuroendocrine probe we studied nine male offenders in a forensic hospital, convicted of murder, with a diagnosis of antisocial personality disorder, who had been behaviourally 'quiescent' for varying periods and who had not recently been abusing drugs. Nine healthy age-matched men also participated. All subjects received 30 mg d-fenfluramine (d-FEN), a 5-HT releasing agent, orally, after an overnight fast, and serial samples for prolactin estimation were taken hourly for five hours. Responses were significantly impaired in the patients, suggesting a subsensitivity of certain 5-HT systems in antisocial personality disorder, regardless of recent or ongoing behavioural disturbance.
Keywords
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