Brain Metabolism during Fasting*
Journal of Clinical InvestigationPublished 1 October 1967Open access
O E Owen, Alfred P. Morgan, H. G. Kemp, James M. Sullivan, M. Guillermo Herrera, George F. Cahill
Citations1,619
SJR quartileQ1
SJR score4.72
SNIP2.17
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TL;DR
Catheterization of cerebral vessels in three obese patients undergoing 5-6 wk of starvation demonstrated that beta-hydroxybutyrate and acetoacetate replaced glucose as the predominant fuel for brain metabolism.
Abstract
Catheterization of cerebral vessels in three obese patients undergoing 5-6 wk of starvation demonstrated that beta-hydroxybutyrate and acetoacetate replaced glucose as the predominant fuel for brain metabolism. A strikingly low respiratory quotient was also observed, suggesting a carboxylation mechanism as a means of disposing of some of the carbon of the consumed substrates.
Keywords
MedicineBiochemistry, Genetics and Molecular Biology
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