Comparison of initiation of protein synthesis in procaryotes, eucaryotes, and organelles
Microbiological ReviewsPublished 1 March 1983Open access
M Kozak
Citations1,274
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TL;DR
The role of mRNA-ribosomal RNA complementarity in eubacterial systems and attempts to Tramnslate mRNAs in Heterologous Systems suggest Dissimilarities in the Initiation Mechanisms.
Keywords
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131 Citations1979John F. Atkins, Joan A. Steitz +2 more
It is shown that the op3 mutation is a C yield U transition occurring in the second codon of the synthetase cistron, which explains the lowered production of phage replicase (as well as lack of lysis) upon op3 infection of nonpermissive cells.
NatureExpression in E. coli of maize and wheat chloroplast genes for large subunit of ribulose bisphosphate carboxylase
131 Citations1981Anthony A. Gatenby, Judith A. Castleton +1 more
Synthesis of the large subunit polypeptide of ribulose bisphosphate carboxylase can be detected in Escherichia coli cells containing the chloroplast genes from maize and wheat.
Journal of Biological ChemistryProtein composition of the bovine mitochondrial ribosome.
129 Citations1982David E. Matthews, Robert Hessler +3 more
The protein complement of the bovine mitochondrial ribosome has been analyzed by two-dimensional electrophoresis in polyacrylamide gels to determine the number and molecular weights of the ribosomal proteins.
Journal of Biological ChemistryIdentification and Mutational Relocation of the AUG Codon Initiating Translation of Iso-1-Cytochrome c in Yeast
128 Citations1971John Stewart, Fred Sherman +2 more
Mutational studies and amino acid sequence analysis were used to identify the initiating methionyl codon AUG as an essential element at the beginning of the genetic message for iso-1-cytochrome c in yeast.
Molecular and Cellular BiologyFactors governing the expression of a bacterial gene in mammalian cells.
127 Citations1981Richard Mulligan, Paul Berg
The structure of the messenger ribonucleic acids (mRNA's) formed during the expression of gpt and an unexpected feature of the nucleotide sequence in the gpt DNA segment are described and infer that the bacterial enzyme can be translated from an initiator AUG that is 400 to 800 nucleotides from the 5' terminus of the mRNA and preceded by two to six AUG triplets.
CellDifferential expression and 5′ end mapping of actin genes in Dictyostelium
127 Citations1981Mick McKeown, Richard Firtel
NatureArchaebacterial elongation factor is ADP-ribosylated by diphtheria toxin
126 Citations1980Michael Kessel, Friedrich Klink
It is reported here that diphtheria toxin also catalyses the ADP-ribosylation of archaebacterial elongation factors, meaning that these factors have to be assigned to the EF2 type; it is assumed that the ADp- ribosylatable structure arising so early in evolution is of fundamental importance for the elongation process.
Nucleic Acids ResearchSequence and secondary structure of Drosophila melanogaster 5.8S and 2S rRNAs and of the processing site between them
123 Citations1979George N. Pavlakis, Bertrand Jordan +2 more
It is concluded that the 5.8S rRNA in Drosophila melanogaster is very similar both in sequence and structure to other5.8 rRNAs but is split into two pieces, the 2S r RNA being the 3' part.
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