Social Isolation Disrupts Autonomic Regulation of the Heart and Influences Negative Affective Behaviors
Biological PsychiatryPublished 21 July 2007Open access
Angela J. Grippo, Damon G. Lamb, C. Sue Carter, Stephen W. Porges
Citations187
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TL;DR
It is indicated that social isolation induces behavioral, cardiac, and autonomic alterations related to those seen after other stressors and which are relevant to cardiovascular disease and affective disorders.
Abstract
These findings indicate that social isolation induces behavioral, cardiac, and autonomic alterations related to those seen after other stressors and which are relevant to cardiovascular disease and affective disorders. This model may provide insight into the mechanisms that underlie these co-occurring conditions.
Keywords
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European Heart JournalHeart rate variability: Standards of measurement, physiological interpretation, and clinical use
15,291 Citations1996Marek Malik, J. Thomas Bigger +5 more
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299 Citations1984
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190 Citations1995E Kristal-Boneh, M Raifel +2 more
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133 Citations1989Leena A. Hilakivi, Mineto Ota +1 more
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130 Citations1987Cameron S. Carter
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88 Citations2001Maria Vittoria Pitzalis, Massimo Iacoviello +7 more
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76 Citations1982Brandon G. Yongue, Philip M. McCabe +4 more
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61 Citations2006Angela J. Grippo, Damon G. Lamb +2 more
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PubMedNew strategies in the search for anxiolytics.
41 Citations1990SE File
The need for animal behavioural tests in the search for novel anxiolytics is discussed and those tests that are ethologically-based are described, including the social interaction, elevated plus-maze, light-dark transitions, and rat pup isolation-induced calling tests.
European Heart Journal SupplementsPrognostic benefits of heart rate reduction in cardiovascular disease
40 Citations2003Roberto Ferrari
Considering that heart rate is a major determinant of oxygen consumption and metabolic demand, heart rate reduction would be expected to diminish cardiac workload.
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27 Citations2003Paul J. Mitchell, S.J. Fairhall +2 more
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Scandinavian Journal of Clinical and Laboratory InvestigationBeneficial effects of vagal stimulation on the ischaemic myocardium during beta-receptor blockade
19 Citations1981John Kjekshus, Arnoldus Schytte Blix +2 more
Vagal stimulation resulted in decreased collateral resistance in the ischaemic area and a marked reduction of myocardial oxygen requirement of both non-ischaemic and border zone myocardium, additional to that obtained with beta receptor blockade.
Acta Physiologica ScandinavicaEffects of adrenal demedullation on stress‐induced hypertension and cardiovascular responses to acute stress
13 Citations1988Stein Knardahl, Brian J. Sanders +1 more
Adrenal demedullation was effective in attenuating plasma A during stress and reduced the plasma noradrenaline response, and the larger pressor responses of the ADM group seem to result from attenuation of beta-adrenoreceptor-mediated dilation of skeletal muscle vasculature.
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