The paradox of nicotinic acetylcholine receptor upregulation by nicotine
Trends in Pharmacological SciencesPublished 1 June 1990
Susan Wonnacott
Citations352
SJR quartileQ1
SJR score3.77
SNIP2.99
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TL;DR
Chronic exposure to agonist or conditions that increase the synaptic concentration of the natural transmitter results in a downregulation of the target receptor, while chronic exposure to antagonist produces an upregulation of receptors.
Abstract
Chronic exposure to agonist (or conditions that increase the synaptic concentration of the natural transmitter, such as blockade of inactivation mechanisms) results in a downregulation of the target receptor. Conversely, chronic exposure to antagonist (or conditions that decrease the synaptic concentration of transmitter, including denervation) produces an upregulation of receptors.
Keywords
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