Studies on the formation of two- and three-stranded polyribonucleotides
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Abstract
The interaction of the synthetic polyribonucleotides, polyadenylic acid and polyuridylic acid has been studied spectrophotometrically by means of the continuous variation technique. The effect of the ionic composition of the solution upon the tendency to form two-stranded and three-stranded complexes is discussed, and it is shown that an excess of small ions is necessary to both reactions. It is found that manganese and magnesium ions have a greater effect than sodium ion in promiting these reactions. It is shown that the two-stranded complex is more stable than the three-stranded complex.