Epidemiology of cancer of the prostate
CancerPublished 1 August 1971
Ernest L. Wynder, Kiyóhiko Mabuchi, Willet F. Whitmore
Citations337
SJR quartileQ1
SJR score2.95
SNIP1.90
Generate an AI Snapshot to get a quick, structured summary of this paper.
Study Snapshot
ObjectiveStudy objective
MethodsResearch methodology
PopulationPopulation studied
Sample sizeSample sizes
OutcomesStudy outcomes here
ResultsStudy results comes here
LimitationsResearch study limitations comes here
A concise AI-generated summary of the paper will appear here once you click Generate AI Snapshot.
TL;DR
No significant relationship was found to socioeconomic status, marital status, fertility, social habits, previous diseases, weight, height, hair distribution, or laboratory data.
Abstract
This study of the epidemiology of cancer of the prostate was based on a retrospective investigation of 300 patients with cancer of the prostate and 400 controls, a review of the charts of an additional 350 patient with prostate cancer, and a review of the literature. The main etiologic lead to which this study could not contribute is the rarity of clinical prostatic cancer in Japan and its increase among Japanese immigrants in the U.S. However, the low rate among Jewish males in the U.S. seems to be related to a lower rate of prostatic cancer among immigrants from Eastern Europe. U.S. Negroes have a higher incidence rate than Caucasians. No significant relationship was found to socioeconomic status, marital status, fertility, social habits, previous diseases, weight, height, hair distribution, or laboratory data.
Keywords
Medicine
The Journal of UrologyStudies on Prostatic Cancer: I. The Effect of Castration, of Estrogen and of Androgen Injection on Serum Phosphatases in Metastatic Carcinoma of the Prostate
3,203 Citations2002Charles Huggins, Clarence V. Hodges
BMJMortality in Relation to Smoking: Ten Years' Observations of British Doctors
680 Citations1964Richard Doll, A. B. Hill
Evidence supports the claim that cigarette smoking is one of the causes of coronary thrombosis under age 75 and continued smoking may prevent or delay the healing of a chronic gastric ulcer and thereby it may increase the mortality rate.
BMJMortality in Relation to Smoking: Ten Years' Observations of British Doctors
544 Citations1964Richard Doll, Amanda Hill
CancerMultiple primary malignant neoplasms.I. Introduction and presentation of data
477 Citations1961Charles G. Moertel, Malcolm B. Dockerty +1 more
The spark of interest generated by Billroth was kept alive by only a few isolated case reports in the later years of the nineteenth century, and the patient with multiple cancers was viewed by the medical profession with the same detached curiosity as the freaks exploited by P. T. Barnum.
Journal of Chronic DiseasesCadmium as a factor in hypertension
301 Citations1965Henry A. Schroeder
Most human subjects dying from hypertensive complications showed in their kidneys either increased concentrations of cadmium or increased ratios of Cadmium to zinc, compared to subjects dying of a variety of other major diseases.
The Journal of UrologyOn The Frequency of Occurrence of Occult Carcinoma of the Prostate
252 Citations1935Arnold R. Rich
JAMAThe Palpable Nodule of Prostatic Cancer
226 Citations1968Hugh J. Jewett
Until Jan 1, 1951, radical perineal prostatectomy was performed on 111 patients with clinically localized and discrete cancer, and in 82 recent cases an improved technique has provided complete urinary control in 80 instances.
JNCI Journal of the National Cancer InstituteCancer Mortality Among the Polish-Born in the United States
207 Citations1965J Staszewski, William Haenszel
The American Journal of MedicineEndocrine changes associated with Laennec's cirrhosis of the liver
203 Citations1948Charles W. Lloyd, Robert H. Williams
In almost all of eighty-seven patients with Laennec's cirrhosis with postmortem examinations at the Mallory Institute of Pathology there was a decrease in lipoid content of the adrenals and in eight of twenty-three patients there was atrophy of the testes.
American Journal of Obstetrics and GynecologyCarcinoma of the endometrium
197 Citations1973Henry Clay Frick, Equinn W. Munnell +3 more
PubMedSome delayed effects of atom-bomb radiations in mice.
161 Citations1960A. C. Upton, A. W. Kimball +3 more
Although the effects of radiation on the incidence and severity of diseases of old age varied markedly from one disease to another, all diseases were advanced in onset to essentially the same extent by any one dose of radiation, with the exception of thymic lymphoma.
Journal of Clinical PathologyLatent Carcinoma of the Prostate
118 Citations1949G. S. Andrews
The incidence of carcinoma of the prostate in 1947 in the United Kingdom, according to the Registrar-General, was 0.98% of all male deaths, whereas several writers have reported a much higher incidence.
CancerMorphogenesis of prostatic carcinoma
117 Citations1965John E. McNeal
In contrast to previous reports, carcinoma seldom seemed to arise from markedly atrophic epithelium, and a relationship between prolonged androgenic stimulation and the development of carcinoma in the prostate is suggested.
British Journal of CancerThe Social Distribution of Cancer in Copenhagen, 1943 to 1947
102 Citations1951J Clemmesen, Aida Nielsen
It is seen that the incidence of cancer as expressed by the figures from the Danish Cancer Registry for 1942 to 1944 was higher for Copenhagen than for the provincial towns, which in their turn exceeded the incidence for rural areas.
CancerThe socioeconomic distribution of cancer of various sites in Buffalo, N.Y., 1948–1952
94 Citations1960Saxon Graham, Morton L. Levin +1 more
Observations of differences in the occurrence of a disease in various socioeconomic groups is of interest since it may provide leads for further investigation and should be followed by study of occupations, areas of residence, and other aspects of the environment or characteristics of the population that are peculiar to socioeconomic groups with high and low rates of the disease.
JNCI Journal of the National Cancer InstituteDistribution of Cancer Mortality Among Ethnic Subgroups of the White Population of New York City, 1953–58<xref ref-type="fn" rid="FN1">2</xref>
91 Citations1961Vaun A. Newill
Archiv für Pathologische Anatomie und Physiologie und für Klinische MedicinZur Frage des Prostatakrebses
87 Citations1938Ellen P. Gaynor
Unter 1040 fortlaufend untersuchten Vorsteherdrüsen von Männern im Alter of 20 bis über 90 Jahren fanden sich 191 Carcinome, was einerallgemeinen Häufigkeit des Vorsteherskrebses von 18,4% entspricht; doch steigt dieser Hundertsatz im höheren Lebensalter.
Journal of Chronic DiseasesSome epidemiological aspects of cancer of the prostate
74 Citations1963Haitung King, Earl L. Diamond +1 more
It is suggested that, as a disease entity in the male genital system, prostatic cancer may be related to a person's sexual behavior, and a systematic, intensive study is necessary in order to gain better insight into possible etiological factors in this site of malignancy.
The American Journal of CancerPathological Conditions Induced by Oestrogenic Compounds in the Coagulating Gland and Prostate of the Mouse
72 Citations1935Harold Burrows
Lesions have been brought about in the coagulating gland and prostate of the mouse by four closely allied oestrogenic substances, namely ketohydroxyoestrin, ketomethoxyoESTrin, trihydroxyoESTrin and equilin2, and they appear worth consideration in connection with human pathology.
PubMedThe effect of the proportion of dietary fat on the rate of formation of mammary carcinoma in mice.
71 Citations1950Herbert Silverstone, Albert Tannenbaum
The mechanism through which fat-enriched diets accelerate the formation of spontaneous mammary carcinoma and carcinogen-induced skin tumors of the mouse is not known and the decrease in energy expenditure of utilization of high-fat rations is too small to account entirely for the observed enhancement of tumor formation.
CancerCorrelations of international cancer death rates.An epidemiological exercise
71 Citations1967Ernest L. Wynder, Lyon Hyams +1 more
An epidemiological interpretation has been attempted in spite of some obvious methodological limitations since these data may serve as a useful tool to substantiate existing epidemiological theory and provide etiological clues.
Environmental ResearchCancer death rates by site and sex for religious and socioeconomic groups in New York City
67 Citations1970Herbert Seidman
Age adjusted death rates by sex are presented for the various sites of cancer for subgroups of the 25–64 year old non-Puerto Rican white population of New York City, 1949–1951, classified jointly by religious group and socioeconomic status.
CancerA comparison of single and multiple primary cancers
60 Citations1966Galen B. Cook
The data suggest that, when cancer first appears in certain tissues, some tissues then have a greater, and some a lesser, likelihood of developing second neoplasms if cancer does begin a second time.
JAMAThe palpable nodule of prostatic cancer. Results 15 years after radical excision
59 Citations1968H. J. Jewett
American Journal of Public Health and the Nations HealthProstatic cancer: relationship to suspended particulate air pollution.
54 Citations1969Warren Winkelstein, Seymour Kantor
The only other positive association between air pollution and a particular cancer present in data from both studies is reported, which is an association between prostatic cancer and suspended particulate air pollution.
British Journal of CancerCancer and Occupation in the Netherlands
49 Citations1949J J Versluys
This investigation into the mortality from carcinoma in the Netherlands during the years 1931-35 is based on the mortality-cards placed at the disposal for inspection by the courtesy of the Registrar-General.
PubMedThe influence of castration on spontaneous tumorigenesis in the Syrian (golden) hamster.
48 Citations1961Joseph G. Fortner
The findings support a working hypothesis that an intrinsic endocrine abnormality may be an important causal factor for the spontaneous tumors in the Syrian (golden) hamster.
ScienceHormone Excretion Patterns in Breast and Prostate Cancer Are Abnormal
46 Citations1964Elizabeth Stern, Carl E. Hopkins +2 more
In patients with breast and prostate cancer hormone excretion patterns differ in a similar way from patterns in persons without cancer.
The Journal of UrologyOccult Carcinoma in Clinically Benign Hypertrophy of the Prostate: A Pathological and Clinical Study
45 Citations1952Morris Labess
Journal of EndocrinologyTHE URINARY EXCRETION OF 11-DEOXY-17-OXOSTEROIDS AND 17-HYDROXYCORTICOSTEROIDS BY NORMAL JAPANESE AND BRITISH WOMEN
37 Citations1967R.D. Bulbrook, B.S. Thomas +2 more
American Journal of Obstetrics and GynecologyEndometrial cancer, obesity, and estrogenic excretion in women
34 Citations1961Gray H. Twombly, Solly Scheiner +1 more
It is propounded that cancer of the endometrium, if it is due to chronic estrogenic stimulation, may occur in obese women frequently because these individuals store estrogens in their fat and possibly thereby prolong the effect of their own hormones on their own endometria.
The Journal of UrologyUrinary Excretion of Neutral 17-ketosteroids and Pregnanediol by Patients with Prostatic Cancer and Benign Prostatic Hypertrophy
31 Citations1965Jessie Marmorston, Louis J. Lombardo +4 more
The Journal of Clinical Endocrinology & MetabolismENDOCRINE STUDIES IN AGING
30 Citations1951Arnold L. Heller, Reginald A. Shipley
The present investigation was concerned with measuring the mean values for the output of pituitary, gonadal, and adrenal cortical hormones in a group of old men and women, to determine possible sex differences, and to compare the values of the -aged group with those encountered in young subjects.
British Journal of CancerInduction of Prostate Tumours in Mice
30 Citations1947E. S. Horning, L. Dmochowski
The Journal of UrologyUrinary Excretion of Estrone, Estradiol and Estriol by Patients with Prostatic Cancer and Benign Prostatic Hypertrophy
28 Citations1965Jessie Marmorston, Louis J. Lombardo +4 more
Experimental Biology and MedicineProtective Effect of Estrogen Against Vascular Damage to the Testis Caused by Cadmium.
27 Citations1965S. A. Gunn, T. C. Gould +1 more
Protection of the testis against vascular injury from cadmium by estrogen was reversible since following cessation of estradiol benzoate treatment and disappearance of tubular atrophy, the testes were again susceptible to Cadmium induced vascular damage.
JAMAOcclusive Disease of Subclavian Artery
18 Citations1966Lester R. Bryant
Fourteen patients with localized atherosclerotic obstruction of the subclavian artery were found to have considerable variation in symptoms, with the most consistent physical finding a difference in blood pressure in the upper extremities of 20 mm Hg or more.
Journal of Epidemiology & Community HealthProstatic cancer and social class.
17 Citations1965I. M. Richardson
A steep rise in mortality in the very old may reflect a real increase in the prevalence of prostatic cancer, but is probably due largely to improved diagnosis and perhaps also to a small extent to greater survival following the introduction of hormone therapy.
JAMAThe Incidence of Carcinoma of the Prostate In Jews and Gentiles
15 Citations1966George W. Kaplan
Differences between ethnic groups have become apparent in the search for clues to the etiologic factors involved in the development of carcinoma of the prostate, and results somewhat different from those obtained by Ravich are found.
The Journal of UrologyRacial Incidence of Prostatism in Hawaii: A Report of 172 Consecutive Cases
13 Citations1947Kyril B. Conger
Journal of NutritionSerum Cholesterol Concentrations of Various Ethnic Groups in Hawaii
12 Citations1960Lucile F. Adamson
The Journal of UrologyCarcinoma of the Prostate in the Absence of Testicular Tissue
12 Citations1960Dennis A. Sharkey, Edwin R. Fisher
The Journal of UrologyMorphological and Biochemical Studies of Virus (SV40) Transformed Prostatic Tissue
11 Citations1969Elwin E. Fraley, David F. Paulson
British Journal of UrologyCARCINOMA OF THE PROSTATE IN JEWS AND CIRCUMCISED GENTILES
9 Citations1954Ella Gibson
Postgraduate MedicineFood Habits and Nutritional Status of American Negroes
4 Citations1965Jean Mayer
In general the nutritional status of Negroes is inferior to that of white persons in the same geographical areas of the United States.